Abstract
Animals received either haloperidol (2 mg/kg) or probenecid (200 mg/kg) in conjunction with tyrosine (100 mg/kg) or its diluent. Striatal homovanillic acid levels increased in probenecid-treated animals to the same range whether they were given tyrosine or not. In haloperidol-treated animals the levels of homovanillic acid were significantly elevated in animals receiving tyrosine. Tyrosine and homovanillic acid levels were highly correlated as determined by linear regression analysis.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brain Chemistry / drug effects*
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Corpus Striatum / enzymology
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Corpus Striatum / metabolism*
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Dopamine / biosynthesis*
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Drug Interactions
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Haloperidol / pharmacology*
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Homovanillic Acid / biosynthesis
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Male
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Probenecid / pharmacology
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Rats
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Tyrosine / pharmacology*
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Tyrosine 3-Monooxygenase / metabolism
Substances
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Tyrosine
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Tyrosine 3-Monooxygenase
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Haloperidol
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Probenecid
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Dopamine
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Homovanillic Acid