Abstract
The zebrafish dorsal habenula (dHb) shows conspicuous asymmetry in its connection with the interpeduncular nucleus (IPN) and is equivalent to the mammalian medial habenula. Genetic inactivation of the lateral subnucleus of dHb (dHbL) biased fish towards freezing rather than the normal flight response to a conditioned fear stimulus, suggesting that the dHbL-IPN pathway is important for controlling experience-dependent modification of fear responses.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adaptation, Physiological / physiology
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Amino Acids / metabolism
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Analysis of Variance
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Animals
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Animals, Genetically Modified
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Behavior, Animal
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Carbocyanines / metabolism
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Conditioning, Classical / physiology
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Electroshock / adverse effects
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Fear / physiology*
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Gene Expression Regulation / physiology*
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Green Fluorescent Proteins / genetics
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HSP72 Heat-Shock Proteins / genetics
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Habenula / cytology
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Habenula / metabolism
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Habenula / physiology*
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In Situ Nick-End Labeling
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Larva
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Locomotion / physiology
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Neural Pathways / physiology
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Neurons / metabolism
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RNA, Messenger / metabolism
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Time Factors
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Transcription Factor Brn-3A / genetics
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Tryptophan Hydroxylase / genetics
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Tryptophan Hydroxylase / metabolism
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Zebrafish / physiology*
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Zebrafish Proteins / genetics
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Zebrafish Proteins / metabolism*
Substances
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Amino Acids
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Carbocyanines
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DNA-Binding Proteins
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HSP72 Heat-Shock Proteins
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RNA, Messenger
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Transcription Factor Brn-3A
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Zebrafish Proteins
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dolaisoleucine
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Green Fluorescent Proteins
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Tryptophan Hydroxylase