The maternal immune activation (MIA) model of schizophrenia produces pre-pulse inhibition (PPI) deficits in both juvenile and adult rats but these effects are not associated with maternal weight loss

Behav Brain Res. 2010 Dec 1;213(2):323-7. doi: 10.1016/j.bbr.2010.05.008. Epub 2010 May 20.

Abstract

The developmental onset of deficits in sensorimotor-gating was examined in the maternal immune activation (MIA) animal model of schizophrenia. Pre-pulse inhibition (PPI) deficits were evident in juvenile MIA rats. This parallels the sensorimotor-gating deficits observed in groups at high-risk of schizophrenia. PPI deficits were independent of maternal weight loss following the MIA manipulation, suggesting that this measure may not be a useful marker of treatment efficacy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Animals
  • Disease Models, Animal*
  • Female
  • Male
  • Poly I-C
  • Pregnancy
  • Prenatal Exposure Delayed Effects / immunology
  • Prenatal Exposure Delayed Effects / psychology*
  • Rats
  • Schizophrenia / immunology*
  • Schizophrenia / physiopathology*
  • Schizophrenic Psychology*
  • Sensory Gating / physiology*
  • Weight Loss

Substances

  • Poly I-C