Abstract
The effect of prenatal exposure to methadone via maternal osmotic minipumps was studied on neurotransmitter content of 4-day-old male and female rats. Several sex-related differences were observed in brain regional neurotransmitter content. Prenatal exposure to methadone produced only selective changes in brain regional neurotransmitter content. Exposure to methadone in doses sufficient to produce maternal and fetal dependence selectively reduced striatal acetylcholine content and produced a sex-dependent change in hindbrain acetylcholine.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Acetylcholine / metabolism
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Animals
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Animals, Newborn / metabolism*
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Brain Chemistry / drug effects
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Corpus Striatum / drug effects
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Corpus Striatum / metabolism
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Dopamine / metabolism
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Female
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Male
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Methadone / pharmacology*
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Neurotransmitter Agents / metabolism*
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Norepinephrine / metabolism
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Pregnancy
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Prenatal Exposure Delayed Effects*
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Rats
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Rats, Inbred Strains
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Serotonin / metabolism
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Sex Factors
Substances
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Neurotransmitter Agents
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Serotonin
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Acetylcholine
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Methadone
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Dopamine
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Norepinephrine