Abstract
Sharp wave-ripple (SPW-R) complexes in the hippocampus-entorhinal cortex are believed to be important for transferring labile memories from the hippocampus to the neocortex for long-term storage. We found that selective elimination of SPW-Rs during post-training consolidation periods resulted in performance impairment in rats trained on a hippocampus-dependent spatial memory task. Our results provide evidence for a prominent role of hippocampal SPW-Rs in memory consolidation.
Publication types
-
Research Support, N.I.H., Extramural
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Action Potentials / physiology
-
Analysis of Variance
-
Animals
-
Behavior, Animal
-
Biophysics
-
Electric Stimulation / methods
-
Electroencephalography / methods
-
Evoked Potentials / physiology*
-
Hippocampus / cytology
-
Hippocampus / physiology*
-
Male
-
Maze Learning / physiology
-
Memory Disorders / physiopathology*
-
Nerve Net / physiology
-
Neural Inhibition / physiology*
-
Neurons / physiology
-
Online Systems
-
Rats
-
Rats, Long-Evans
-
Space Perception / physiology*
-
Spectrum Analysis / methods