Genomic anatomy of the hippocampus

Neuron. 2008 Dec 26;60(6):1010-21. doi: 10.1016/j.neuron.2008.12.008.

Abstract

Availability of genome-scale in situ hybridization data allows systematic analysis of genetic neuroanatomical architecture. Within the hippocampus, electrophysiology and lesion and imaging studies demonstrate functional heterogeneity along the septotemporal axis, although precise underlying circuitry and molecular substrates remain uncharacterized. Application of unbiased statistical component analyses to genome-scale hippocampal gene expression data revealed robust septotemporal molecular heterogeneity, leading to the identification of a large cohort of genes with robust regionalized hippocampal expression. Manual mapping of heterogeneous CA3 pyramidal neuron expression patterns demonstrates an unexpectedly complex molecular parcellation into a relatively coherent set of nine expression domains in the septal/temporal and proximal/distal axes with reciprocal, nonoverlapping boundaries. Unique combinatorial profiles of adhesion molecules within these domains suggest corresponding differential connectivity, which is demonstrated for CA3 projections to the lateral septum using retrograde labeling. This complex, discrete molecular architecture provides a novel paradigm for predicting functional differentiation across the full septotemporal extent of the hippocampus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Animals, Newborn
  • Brain Mapping*
  • Cholera Toxin / metabolism
  • Gene Expression Regulation, Developmental / physiology*
  • Genomics*
  • Hippocampus / anatomy & histology*
  • Hippocampus / physiology*
  • Imaging, Three-Dimensional
  • In Situ Hybridization / methods
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Models, Biological
  • Nerve Tissue Proteins / genetics
  • Nerve Tissue Proteins / metabolism
  • Neural Cell Adhesion Molecules / genetics
  • Neural Cell Adhesion Molecules / metabolism
  • Neural Pathways / anatomy & histology
  • Neural Pathways / metabolism
  • Principal Component Analysis
  • Septum Pellucidum / anatomy & histology
  • Septum Pellucidum / metabolism
  • Temporal Lobe / anatomy & histology
  • Temporal Lobe / metabolism

Substances

  • Nerve Tissue Proteins
  • Neural Cell Adhesion Molecules
  • Cholera Toxin