Abstract
Separate groups of food-deprived rats were given 2h access to food after receiving bilateral nucleus accumbens infusions of the muscarinic antagonist scopolamine methyl bromide (at 0, 1.0, and 10.0 microg/side), the M2-preferring agonist oxotremorine sesquifumarate (Oxo-S; at 0, 1.0, or 10.0 microg/side) or the M2 antagonist AFDX-116 (at 0, 0.2, or 1.0 microg/side). Injections of scopolamine or Oxo-S, but not AFDX-116, reduced food consumption across the 2h. These experiments confirm a critical role for Acb acetylcholine in promoting food ingestion, and suggest that decreased acetylcholine tone at post-synaptic muscarinic receptors disrupts normal consummatory behavior.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetylcholine / physiology*
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Animals
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Dose-Response Relationship, Drug
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Eating / drug effects*
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Eating / physiology
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Feeding Behavior / drug effects*
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Feeding Behavior / physiology
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Male
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Microinjections
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Muscarinic Agonists / administration & dosage
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Muscarinic Agonists / pharmacology
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Muscarinic Antagonists / administration & dosage
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Muscarinic Antagonists / pharmacology
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N-Methylscopolamine / administration & dosage
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N-Methylscopolamine / pharmacology
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / physiology*
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Oxotremorine / administration & dosage
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Oxotremorine / analogs & derivatives
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Oxotremorine / pharmacology
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Parasympatholytics / administration & dosage
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Parasympatholytics / pharmacology
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Pirenzepine / administration & dosage
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Pirenzepine / analogs & derivatives
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Pirenzepine / pharmacology
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Rats
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Rats, Sprague-Dawley
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Receptors, Muscarinic / drug effects
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Receptors, Muscarinic / physiology*
Substances
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Muscarinic Agonists
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Muscarinic Antagonists
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Parasympatholytics
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Receptors, Muscarinic
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oxotremorine sesquifumarate
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Pirenzepine
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Oxotremorine
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Acetylcholine
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otenzepad
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N-Methylscopolamine