Abstract
RDC8 has been recently cloned and characterized as an adenosine A2 receptor. This receptor is expressed exclusively by medium-sized neurons of the striatum as demonstrated by in situ hybridization. We have now studied the relationship of this receptor with three major components of the rat caudate-putamen: enkephalin, substance P, and choline acetyltransferase. Our results demonstrate that the adenosine A2 receptor is expressed exclusively by the enkephalinergic striatal subpopulation but not by the substance P-containing or cholinergic neurons.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Choline O-Acetyltransferase / genetics
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Choline O-Acetyltransferase / metabolism
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Choline O-Acetyltransferase / physiology
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Corpus Striatum / metabolism
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Corpus Striatum / physiology
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Corpus Striatum / ultrastructure*
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Enkephalins / genetics
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Enkephalins / metabolism*
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Enkephalins / physiology
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Gene Expression
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Histocytochemistry
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Male
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Neurons / metabolism*
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Neurons / physiology
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Neurons / ultrastructure
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Nucleic Acid Hybridization
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RNA, Messenger / genetics
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RNA, Messenger / metabolism
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Rats
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Rats, Inbred Strains
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Receptors, Purinergic / genetics
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Receptors, Purinergic / metabolism*
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Receptors, Purinergic / physiology
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Substance P / genetics
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Substance P / metabolism*
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Substance P / physiology
Substances
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Enkephalins
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RNA, Messenger
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Receptors, Purinergic
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Substance P
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Choline O-Acetyltransferase