Abstract
Olfactory information is first encoded in a combinatorial fashion by olfactory bulb glomeruli, which individually represent distinct chemical features of odors. This information is then transmitted to piriform (olfactory) cortex, via axons of olfactory bulb mitral and tufted (M/T) cells, where it is presumed to form the odor percept. However, mechanisms governing the integration of sensory information in mammalian olfactory cortex are unclear. Here we show that single M/T cells can make powerful connections with cortical pyramidal cells, and coincident input from few M/T cells is sufficient to elicit spike output. These findings suggest that odor coding is broad and distributed in olfactory cortex.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Action Potentials / drug effects
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Action Potentials / physiology
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Action Potentials / radiation effects
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Anesthetics, Local / pharmacology
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Animals
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Animals, Newborn
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Cerebral Cortex / cytology*
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Dose-Response Relationship, Radiation
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Electric Stimulation / methods
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Excitatory Postsynaptic Potentials / drug effects
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Excitatory Postsynaptic Potentials / physiology
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Excitatory Postsynaptic Potentials / radiation effects
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GABA Antagonists / pharmacology
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In Vitro Techniques
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Nerve Fibers / physiology*
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Nerve Fibers / radiation effects
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Odorants*
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Olfactory Mucosa / cytology
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Olfactory Mucosa / physiology
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Olfactory Pathways / drug effects
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Olfactory Pathways / physiology*
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Olfactory Receptor Neurons / drug effects
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Olfactory Receptor Neurons / physiology*
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Patch-Clamp Techniques / methods
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Picrotoxin / pharmacology
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Pyramidal Cells / drug effects
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Pyramidal Cells / physiology*
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Rats
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Reaction Time / drug effects
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Reaction Time / physiology
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Reaction Time / radiation effects
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Strontium / pharmacology
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Tetrodotoxin / pharmacology
Substances
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Anesthetics, Local
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GABA Antagonists
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Picrotoxin
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Tetrodotoxin
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Strontium