Abstract
Endogenous cannabinoids (eCB) mediate synaptic plasticity in brain regions involved in learning and reward. Here we show that in mice, a single in-vivo exposure to Delta 9-tetrahydrocannabinol (THC) abolishes the retrograde signaling that underlies eCB-mediated synaptic plasticity in both nucleus accumbens (NAc) and hippocampus in vitro. This effect is reversible within 3 days and is associated with a transient modification in the functional properties of cannabinoid receptors.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Cannabinoid Receptor Modulators / antagonists & inhibitors*
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Cannabinoid Receptor Modulators / physiology
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Dose-Response Relationship, Drug
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Dronabinol / administration & dosage*
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Endocannabinoids*
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Hippocampus / drug effects
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Hippocampus / physiology
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In Vitro Techniques
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Mice
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Neuronal Plasticity / drug effects*
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Neuronal Plasticity / physiology
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Nucleus Accumbens / drug effects
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Nucleus Accumbens / physiology
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Synapses / drug effects*
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Synapses / physiology
Substances
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Cannabinoid Receptor Modulators
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Endocannabinoids
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Dronabinol