Multiple sclerosis: deeper understanding of its pathogenesis reveals new targets for therapy

Annu Rev Neurosci. 2002:25:491-505. doi: 10.1146/annurev.neuro.25.112701.142913. Epub 2002 Mar 27.

Abstract

Recent technological breakthroughs allowing for large-scale analysis of gene transcripts and large-scale monitoring of the immune response with protein chips are revealing new participants in the pathogenesis of multiple sclerosis. Some of these participants may be useful targets for therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Central Nervous System / immunology*
  • Central Nervous System / pathology
  • Central Nervous System / physiopathology
  • Gene Expression Regulation / immunology
  • Humans
  • Inflammation Mediators / immunology
  • Lymphocytes / immunology
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / immunology*
  • Multiple Sclerosis / therapy
  • Myelin Sheath / immunology*
  • Myelin Sheath / pathology

Substances

  • Inflammation Mediators