Abstract
The "funny" (pacemaker) current has unusual characteristics, including activation on hyperpolarization, permeability to K(+) and Na(+), modulation by internal cAMP, and a tiny, single-channel conductance. In cardiac cells and neurons, pacemaker channels control repetitive activity and excitability. The recent cloning of HCN subunits provides new insight into the molecular basis for the funny channel properties.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Cyclic Nucleotide-Gated Cation Channels
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Electrophysiology
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Humans
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Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
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Ion Channel Gating / physiology
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Ion Channels / chemistry
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Ion Channels / physiology*
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Kinetics
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Nerve Tissue Proteins*
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Nucleotides, Cyclic / physiology
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Potassium Channels
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Protein Processing, Post-Translational
Substances
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Cyclic Nucleotide-Gated Cation Channels
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Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
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Ion Channels
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Nerve Tissue Proteins
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Nucleotides, Cyclic
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Potassium Channels