Abstract
The tachykinins substance P and neurokinin A participate in the regulation of gastrointestinal motility, secretion, vascular permeability and pain sensitivity. Advances made during the past two years corroborate a causal involvement of tachykinins in inflammation-induced disturbances of gut function, such as dysmotility, secretory diarrhoea, oedema and hyperalgesia. It would therefore appear that tachykinin receptors, which in the digestive system are expressed in a cell-specific manner, represent attractive targets for novel therapeutics in gastroenterology.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Colonic Diseases, Functional / drug therapy
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Digestive System / metabolism
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Digestive System / pathology
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Digestive System Physiological Phenomena*
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Gastrointestinal Diseases / drug therapy
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Gastrointestinal Diseases / metabolism*
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Gastrointestinal Diseases / pathology
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Gastrointestinal Motility
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Humans
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Inflammatory Bowel Diseases / drug therapy
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Neurokinin A / metabolism
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Neurokinin A / physiology
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Receptors, Neurokinin-1 / metabolism
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Receptors, Neurokinin-2 / metabolism
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Receptors, Neurokinin-3 / metabolism
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Receptors, Tachykinin / antagonists & inhibitors
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Receptors, Tachykinin / metabolism*
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Substance P / metabolism
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Substance P / physiology
Substances
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Receptors, Neurokinin-1
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Receptors, Neurokinin-2
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Receptors, Neurokinin-3
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Receptors, Tachykinin
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Substance P
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Neurokinin A