Transcriptional regulation by the phosphorylation-dependent factor CREB

Nat Rev Mol Cell Biol. 2001 Aug;2(8):599-609. doi: 10.1038/35085068.

Abstract

The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?

Publication types

  • Review

MeSH terms

  • Activating Transcription Factor 1
  • Alternative Splicing
  • Animals
  • Binding Sites
  • Cyclic AMP / physiology
  • Cyclic AMP Response Element Modulator
  • Cyclic AMP Response Element-Binding Protein / chemistry
  • Cyclic AMP Response Element-Binding Protein / genetics
  • Cyclic AMP Response Element-Binding Protein / physiology*
  • Cyclic AMP-Dependent Protein Kinases / physiology
  • DNA Methylation
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology
  • Gene Expression Regulation / physiology*
  • Gene Products, tax / physiology
  • Growth Substances / physiology
  • Human T-lymphotropic virus 1 / genetics
  • Leucine Zippers
  • Macromolecular Substances
  • Mice
  • Mice, Knockout
  • Mice, Transgenic
  • Models, Genetic
  • Models, Molecular
  • Multigene Family
  • Nuclear Proteins / physiology
  • Phosphorylation
  • Protein Conformation
  • Protein Processing, Post-Translational
  • Regulatory Sequences, Nucleic Acid
  • Repressor Proteins*
  • Second Messenger Systems / physiology
  • Stress, Physiological / genetics
  • Stress, Physiological / metabolism
  • Trans-Activators / physiology
  • Transcription Factors / physiology
  • Transcription, Genetic*

Substances

  • Activating Transcription Factor 1
  • Atf1 protein, mouse
  • Cyclic AMP Response Element-Binding Protein
  • DNA-Binding Proteins
  • Gene Products, tax
  • Growth Substances
  • Macromolecular Substances
  • Nuclear Proteins
  • Repressor Proteins
  • Trans-Activators
  • Transcription Factors
  • Cyclic AMP Response Element Modulator
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases