Abstract
The content of catecholamines and their metabolites in the brain and the relationship between cerebral catecholamine levels and their urinary excretion were studied in rats with 6-OHDA-induced hemiparkinsonism. 6-OHDA reduced brain concentrations of dopamine, DOPAC, and homovanilic acid and urinary excretion of dopamine, dioxyphenilalanine, and DOPAC by more than 90%. A positive correlation was found between the concentrations of these metabolites in the urine and striatum. Measurement of urinary catecholamines and their metabolites is a perspective test for evaluating the status of the dopaminergic nigrosostriate system of the brain in experimental parkinsonism.
MeSH terms
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3,4-Dihydroxyphenylacetic Acid / metabolism
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3,4-Dihydroxyphenylacetic Acid / urine
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Animals
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Brain / metabolism*
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Brain / pathology
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Catecholamines / metabolism*
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Catecholamines / urine
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Dihydroxyphenylalanine / metabolism
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Dihydroxyphenylalanine / urine
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Dopamine / metabolism
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Dopamine / urine
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Epinephrine / metabolism
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Epinephrine / urine
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Homovanillic Acid / metabolism
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Homovanillic Acid / urine
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Male
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Methoxyhydroxyphenylglycol / analogs & derivatives*
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Methoxyhydroxyphenylglycol / metabolism
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Methoxyhydroxyphenylglycol / urine
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Norepinephrine / metabolism
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Norepinephrine / urine
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Oxidopamine / toxicity
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Parkinsonian Disorders / chemically induced
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Parkinsonian Disorders / metabolism*
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Parkinsonian Disorders / pathology
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Parkinsonian Disorders / urine
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Rats
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Rats, Wistar
Substances
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Catecholamines
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3,4-Dihydroxyphenylacetic Acid
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Methoxyhydroxyphenylglycol
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Dihydroxyphenylalanine
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Oxidopamine
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3,4-dihydroxyphenylglycol
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Dopamine
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Norepinephrine
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Homovanillic Acid
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Epinephrine