Abstract
Mutations of the mouse Lps locus abolish responses to lipopolysaccharide (LPS). Positional cloning work has revealed that Lps encodes the Toll-like receptor 4 (Tlr4), which functions as the transmembrane component of the LPS receptor complex, an unduplicated pathway for the detection of endotoxin. The structurally related protein Tlr2 makes no contribution to LPS signal transduction.
MeSH terms
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Alleles
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Drosophila Proteins*
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Genes, Dominant
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Genes, Recessive
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Insect Proteins / genetics
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Lipopolysaccharide Receptors / genetics
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Lipopolysaccharide Receptors / metabolism*
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Lipopolysaccharides / immunology*
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Membrane Glycoproteins / genetics
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Membrane Glycoproteins / metabolism*
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Models, Immunological
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Receptors, Cell Surface / genetics
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Receptors, Cell Surface / metabolism*
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Signal Transduction
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Toll-Like Receptor 2
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Toll-Like Receptor 4
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Toll-Like Receptors
Substances
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Drosophila Proteins
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Insect Proteins
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Lipopolysaccharide Receptors
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Lipopolysaccharides
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Membrane Glycoproteins
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Receptors, Cell Surface
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Tl protein, Drosophila
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Toll-Like Receptor 2
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Toll-Like Receptor 4
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Toll-Like Receptors