Formation of Electrically Active Clusterized Neural Networks

Ronen Segev, Morris Benveniste, Yoash Shapira, and Eshel Ben-Jacob
Phys. Rev. Lett. 90, 168101 – Published 21 April 2003

Abstract

Ordinarily, in vitro neurons self-organize into homogeneous networks of single neurons linked by dendrites and axons. We show that under special conditions they can also self-organize into neuronal clusters, which are linked by bundles of axons. Multielectrode array measurement reveals that the clusterized networks are also electrically active and exhibit synchronized bursting events similar to those observed in the homogeneous networks. From time-lapse recording, we deduced the features required for the neuronal clusterized versus homogeneous self-organization and developed a simple model for testing their validity.

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  • Received 1 July 2002

DOI:https://doi.org/10.1103/PhysRevLett.90.168101

©2003 American Physical Society

Authors & Affiliations

Ronen Segev

  • School of Physics and Astronomy, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel
  • Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544

Morris Benveniste

  • Department of Physiology & Pharmacology, Sackler Faculty of Medicine Tel-Aviv University, Tel-Aviv 69978, Israel

Yoash Shapira and Eshel Ben-Jacob

  • School of Physics and Astronomy, Raymond & Beverly Sackler Faculty of Exact Sciences, Tel-Aviv University, Tel-Aviv 69978, Israel

  • *Electronic address: eshel@tamar.tau.ac.il

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Issue

Vol. 90, Iss. 16 — 25 April 2003

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