Dominant mesial temporal lobe resection for pharmacoresistant epilepsy is frequently associated with verbal memory impairment. More-extensive lesioning improves seizure outcome, but further compromises memory. A better understanding of ipsilateral neural structures and networks for verbal memory could improve selectivity of surgical ablation, thereby holding promise for seizure-freedom without memory impairment.
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Duchowny, M., Bhatia, S. Preserving memory in temporal lobectomy—are networks the key?. Nat Rev Neurol 10, 245–246 (2014). https://doi.org/10.1038/nrneurol.2014.67
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DOI: https://doi.org/10.1038/nrneurol.2014.67
