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Multisensory representation of limb position in human premotor cortex

Nature Neuroscience volume 6, pages 17–18 (2003)Cite this article

Abstract

Using functional magnetic resonance imaging (fMRI) in humans, we identified regions of cortex involved in the encoding of limb position. Tactile stimulation of the right hand, across the body midline, activated the right parietal cortex when the eyes were closed; activation shifted to a left parietofrontal network when the eyes were open. These data reveal important similarities between human and non-human primates in the network of brain areas involved in the multisensory representation of limb position.

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Figure 1: Within-subjects group analyses of activation contrasts.
Figure 2: Activation specific to the position of the left hand across the body midline with the eyes open (within-subjects group analysis).

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References

  1. Groh, J.M. & Sparks, D.L. J. Neurophysiol. 75, 412–427 (1996).

    Article  CAS  Google Scholar 

  2. Shore, D.I., Spry, E. & Spence, C. Cogn. Brain Res. 14, 153–163 (2002).

    Article  Google Scholar 

  3. Yamamoto, S. & Kitazawa, S. Nat. Neurosci. 4, 759–765 (2001).

    Article  CAS  Google Scholar 

  4. Bradshaw, J.L., Bradshaw, J.A., Pierson-Savage, J.M. & Nettleton, N.C. Can. J. Psychol. 42, 44–56 (1988).

    Article  CAS  Google Scholar 

  5. Pierson-Savage, J.M., Bradshaw, J.L., Bradshaw, J.A. & Nettleton, N.C. Brain 111, 1531–1545 (1988).

    Article  Google Scholar 

  6. Ladavas, E., Farne, A., Zeloni, G. & di Pellegrino, G. Exp. Brain Res. 131, 458–467 (2000).

    Article  CAS  Google Scholar 

  7. Botvinick, M. & Cohen, J. Nature 391, 756 (1998).

  8. Pavani, F., Spence, C. & Driver, J. Psychol. Sci. 11, 353–359 (2000).

    Article  CAS  Google Scholar 

  9. Wolpert, D.M., Goodbody, S.J. & Husain, M. Nat. Neurosci. 1, 529–533 (1998).

    Article  CAS  Google Scholar 

  10. Graziano, M.S. Proc. Natl. Acad. Sci. USA 96, 10418–10421 (1999).

    Article  CAS  Google Scholar 

  11. Rizzolatti, G., Fogassi, L. & Gallese, V. Curr. Opin. Neurobiol. 12, 149–154 (2002).

    Article  CAS  Google Scholar 

  12. Spence, C., Kingstone, A., Shore, D.I. & Gazzaniga, M.S. Psychol. Sci. 12, 90–93 (2001).

    Article  CAS  Google Scholar 

  13. Obayashi, S., Tanaka, M. & Iriki, A. Neuroreport 11, 3499–3505 (2000).

    Article  CAS  Google Scholar 

  14. Beltramello, A. et al. Ital. J. Neurol. Sci. 19, 277–284 (1998).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors thank E. Ladavas, J. Enns, A. Maravita and E. Macaluso for comments on the manuscript and the University of Oxford McDonnell-Pew Centre for Cognitive Neuroscience for funding a Network Grant to all of the authors. D.M.L. was supported by the Medical Research Council (UK), and D.I.S. was supported by the Natural Science and Engineering Council of Canada; G.A.C. was supported by a Career Development Award from the Wellcome Trust (UK).

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Authors and Affiliations

  1. FMRIB Centre, John Radcliffe Hospital, Oxford, OX3 9DU, UK

    Donna M. Lloyd

  2. Department of Psychology, McMaster University, Hamilton, L8S 4K1, Ontario, Canada

    David I. Shore

  3. Department of Experimental Psychology, University of Oxford, Oxford, OX1 3UD, UK

    Charles Spence

  4. University Laboratory of Physiology, University of Oxford, Oxford, OX1 3PT, UK

    Gemma A. Calvert

Authors
  1. Donna M. Lloyd
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  2. David I. Shore
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  3. Charles Spence
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  4. Gemma A. Calvert
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Correspondence to David I. Shore.

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The authors declare no competing financial interests.

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Lloyd, D., Shore, D., Spence, C. et al. Multisensory representation of limb position in human premotor cortex. Nat Neurosci 6, 17–18 (2003). https://doi.org/10.1038/nn991

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