Abstract
Remembering often requires the selection of goal-relevant memories in the face of competition from irrelevant memories. Although there is a cost of selecting target memories over competing memories (increased forgetting of the competing memories), here we report neural evidence for the adaptive benefits of forgetting—namely, reduced demands on cognitive control during future acts of remembering. Functional magnetic resonance imaging during selective retrieval showed that repeated retrieval of target memories was accompanied by dynamic reductions in the engagement of functionally coupled cognitive control mechanisms that detect (anterior cingulate cortex) and resolve (dorsolateral and ventrolateral prefrontal cortex) mnemonic competition. Strikingly, regression analyses revealed that this prefrontal disengagement tracked the extent to which competing memories were forgotten; greater forgetting of competing memories was associated with a greater decline in demands on prefrontal cortex during target remembering. These findings indicate that, although forgetting can be frustrating, memory might be adaptive because forgetting confers neural processing benefits.
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Change history
10 June 2007
figure 3a y axis
Notes
*NOTE: In the version of this article initially published online, the x-axis in Figure 3a was labeled incorrectly. The error has been corrected for all versions of the article.
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Acknowledgements
Supported by the National Institute of Mental Health (1R01MH080309–01), National Science Foundation (BCS–0401641), McKnight Endowment Fund for Neuroscience and Alfred P. Sloan Foundation.
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Supplementary information
Supplementary Fig. 1
Dissociations and overlap between effects of retrieval success and retrieval repetition. (PDF 275 kb)
Supplementary Table 1
Frontoparietal regions more active during first successful retrieval than third successful retrieval during retrieval practice. (PDF 50 kb)
Supplementary Table 2
Regions in which repetition-related changes in activation are predictive of long-term competitor forgetting. (PDF 47 kb)
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Kuhl, B., Dudukovic, N., Kahn, I. et al. Decreased demands on cognitive control reveal the neural processing benefits of forgetting. Nat Neurosci 10, 908–914 (2007). https://doi.org/10.1038/nn1918
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DOI: https://doi.org/10.1038/nn1918
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