Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Capacity for 5-HT1A–mediated autoregulation predicts amygdala reactivity

A Corrigendum to this article was published on 01 February 2007

Abstract

We examined the contribution of 5-HT1A autoreceptors (with [11C]WAY100635 positron emission tomography) to amygdala reactivity (with blood oxygenation level–dependent functional magnetic resonance imaging) in 20 healthy adult volunteers. We found a significant inverse relationship wherein 5-HT1A autoreceptor density predicted a notable 30–44% of the variability in amygdala reactivity. Our data suggest a potential molecular mechanism by which a reduced capacity for negative feedback regulation of 5-HT release is associated with increased amygdala reactivity.

This is a preview of subscription content, access via your institution

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: 5-HT1A autoreceptor availability predicts amygdala reactivity.

Similar content being viewed by others

References

  1. Lemonde, S. et al. J. Neurosci. 23, 8788–8799 (2003).

    Article  CAS  Google Scholar 

  2. Parsey, R.V. et al. Biol. Psychiatry 59, 106–113 (2006).

    Article  CAS  Google Scholar 

  3. Blier, P. & de Montigny, C. Neuropsychopharmacology 21, 91S–98S (1999).

    Article  CAS  Google Scholar 

  4. Hasler, G., Drevets, W.C., Manji, H.K. & Charney, D.S. Neuropsychopharmacology 29, 1765–1781 (2004).

    Article  CAS  Google Scholar 

  5. Parks, C.L., Robinson, P.S., Sibille, E., Shenk, T. & Toth, M. Proc. Natl. Acad. Sci. USA 95, 10734–10739 (1998).

    Article  CAS  Google Scholar 

  6. Klemenhagen, K.C., Gordon, J.A., David, D.J., Hen, R. & Gross, C.T. Neuropsychopharmacology 31, 101–111 (2006).

    Article  CAS  Google Scholar 

  7. Arborelius, L. IDrugs 2, 121–128 (1999).

    CAS  PubMed  Google Scholar 

  8. Lemonde, S., Du, L., Bakish, D., Hrdina, P. & Albert, P.R. Int. J. Neuropsychopharmacol. 7, 501–506 (2004).

    Article  CAS  Google Scholar 

  9. LeDoux, J.E. Annu. Rev. Neurosci. 23, 155–184 (2000).

    Article  CAS  Google Scholar 

  10. David, S.P. et al. J. Neurosci. 25, 2586–2590 (2005).

    Article  CAS  Google Scholar 

  11. Caspi, A. et al. Science 301, 386–389 (2003).

    Article  CAS  Google Scholar 

  12. Hariri, A.R. et al. Science 297, 400–403 (2002).

    Article  CAS  Google Scholar 

Download references

Acknowledgements

We thank S. Hulland, S. Brown and J. James for technical assistance. This work was supported by grants from the National Institute of Mental Health (MH072837 to A.R.H., and MH067602 and MH64625 to C.C.M.) and from the National Alliance for Research on Schizophrenia and Depression (Young Investigator Award to A.R.H.).

Author information

Authors and Affiliations

Authors

Contributions

A.R.H. designed the study as a component of a parent study directed by C.C.M. P.M.F. and S.K.Z. performed the phenotype assessment. E.L.M.-K., C.C.M. and S.L.B. contributed to subject assessment, recruitment and data collection. A.R.H., P.M.F., J.C.P. and S.K.Z. participated in data analysis and interpretation. All authors reviewed and approved the final manuscript.

Corresponding author

Correspondence to A R Hariri.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Supplementary information

Rights and permissions

Reprints and permissions

About this article

Cite this article

Fisher, P., Meltzer, C., Ziolko, S. et al. Capacity for 5-HT1A–mediated autoregulation predicts amygdala reactivity. Nat Neurosci 9, 1362–1363 (2006). https://doi.org/10.1038/nn1780

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nn1780

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing