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Out of control in the dendrites

Although voltage-clamp recordings remain a favorite method for studying synaptic transmission, the space-clamp problems that are associated with somatic voltage-clamp recordings have never been directly measured. A study by Williams and Mitchell in this issue now measures the experimental errors associated with this technique.

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Figure 1: Diagram depicting the poor space clamp of dendritic conductances from the experiments of Williams and Mitchell2.

References

  1. Hodgkin, A.L., Huxley, A.F. & Katz, B. J. Physiol. (Lond.) 116, 424–448 (1952).

    Article  CAS  Google Scholar 

  2. Williams, S.R. & Mitchell, S.J. Nat. Neurosci. 11, 790–798 (2008).

    Article  CAS  Google Scholar 

  3. Adrian, R.H., Chandler, W.J. & Hodgkin, A.L. J. Physiol. (Lond.) 208, 607–644 (1970).

    Article  CAS  Google Scholar 

  4. Julian, F.J., Moore, J.W. & Goldman, D.E. J. Gen. Physiol. 45, 1195 (1962).

    Article  CAS  Google Scholar 

  5. Neher, E. & Lux, H.D. Pflugers Arch. 311, 272–277 (1969).

    Article  CAS  Google Scholar 

  6. Hamill, O.P., Marty, A., Neher, E., Sakmann, B. & Sigworth, F.J. Pflugers Arch. 391, 85–100 (1981).

    Article  CAS  Google Scholar 

  7. Spruston, N., Jaffe, D.B. & Johnston, D. Trends Neurosci. 17, 161–166 (1994).

    Article  CAS  Google Scholar 

  8. Rall, W. & Segev, I. in Voltage and Patch Clamping with Microelectrodes (eds Smith, T.G., Lecar, H., Redman, S.J. & Gage, P.W.) 191–215 (American Physiological Society, Bethesda, Maryland, 1985).

    Book  Google Scholar 

  9. Sharp, A.A., O'Neil, M.B., Abbott, L.F. & Marder, E. Trends Neurosci. 16, 389–394 (1993).

    Article  CAS  Google Scholar 

  10. Magee, J.C. & Cook, E.P. Nat. Neurosci. 3, 895–903 (2000).

    Article  CAS  Google Scholar 

  11. Pearce, R.A. Neuron 10, 189–200 (1993).

    Article  CAS  Google Scholar 

  12. Häusser, M. & Roth, A. J. Neurosci. 17, 7606–7625 (1997).

    Article  Google Scholar 

  13. Bar-Yehuda, D. & Korngreen, A. J. Neurophysiol. 99, 1127–1136 (2008).

    Article  Google Scholar 

  14. Kim, S.J. & Linden, D.J. Neuron 56, 582–592 (2007).

    Article  CAS  Google Scholar 

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Spruston, N., Johnston, D. Out of control in the dendrites. Nat Neurosci 11, 733–734 (2008). https://doi.org/10.1038/nn0708-733

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