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A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Nature Neuroscience volume 18, pages 1565–1567 (2015)Cite this article

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Abstract

We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

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Figure 1: CCA mode subject measure weights, connectome weights and data variance explained.
Figure 2: CCA mode connectome weights and associated spatial maps.

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Acknowledgements

We thank our many colleagues in the WU-Minn HCP Consortium for their invaluable contributions in generating the publicly available HCP data and implementing the procedures needed to acquire, analyze, visualize and share these data sets. We are grateful for funding from the US National Institutes of Health (grants 1U54MH091657, P30-NS057091, P41-RR08079/EB015894 and F30-MH097312) and the Wellcome Trust (grants 098369/Z/12/Z and 091509/Z/10/Z).

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Authors and Affiliations

  1. Oxford University Centre for Functional MRI of the Brain (FMRIB), Oxford, UK

    Stephen M Smith, Anderson M Winkler, Timothy E J Behrens & Karla L Miller

  2. Department of Statistics and Warwick Manufacturing Group, University of Warwick, Coventry, UK

    Thomas E Nichols

  3. Oxford University Centre for Human Brain Activity (OHBA), Oxford, UK

    Diego Vidaurre

  4. Washington University School of Medicine, Washington University, St. Louis, Missouri, USA

    Matthew F Glasser, Deanna M Barch & David C Van Essen

  5. Center for Magnetic Resonance Research, University of Minnesota, Minnesota, USA

    Kamil Ugurbil

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  1. Stephen M Smith
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  6. Matthew F Glasser
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  7. Kamil Ugurbil
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  9. David C Van Essen
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Contributions

D.V.E., K.U., D.B., T.B., M.G. and S.S. contributed to the data acquisition and image processing. S.S., K.M., T.N., D.V., A.W. and T.B. designed and carried out the statistical analyses. All of the authors contributed to writing the paper.

Corresponding author

Correspondence to Stephen M Smith.

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The authors declare no competing financial interests.

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Supplementary Figures 1–4 and Supplementary Tables 1 and 2 (PDF 4287 kb)

Supplementary Methods Checklist (PDF 384 kb)

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Smith, S., Nichols, T., Vidaurre, D. et al. A positive-negative mode of population covariation links brain connectivity, demographics and behavior. Nat Neurosci 18, 1565–1567 (2015). https://doi.org/10.1038/nn.4125

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