Abstract
Depolarization by the neurotransmitter GABA regulates adult neurogenesis. We found interneurons of the neurogliaform cell family to be a primary source of GABA for newborn neurons in mouse dentate gyrus. GABAergic depolarization occurred in concert with reduced synaptic inhibition of mature neurons, suggesting that the local circuitry coordinates the activation of new and pre-existing cells.
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Acknowledgements
We thank members of the Wadiche laboratory and A. Tzingounis for helpful comments, and A. Margolies and C. Zhao for technical assistance. This work was supported by grants from the US National Institutes of Health (5T32GM008111, 5R01NS064025 and 2P30NS047466).
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Markwardt, S., Dieni, C., Wadiche, J. et al. Ivy/neurogliaform interneurons coordinate activity in the neurogenic niche. Nat Neurosci 14, 1407–1409 (2011). https://doi.org/10.1038/nn.2935
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DOI: https://doi.org/10.1038/nn.2935
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