Abstract
The medial entorhinal cortex (MEC) is a major center for spatial navigation and memory. We found that cannabinoid type 1 receptor–expressing GABAergic basket cells selectively innervated principal cells in layer II of the rat MEC that projected outside the hippocampus but avoided neighboring cells that give rise to the perforant pathway to the dentate gyrus. These results indicate that the organization of GABAergic microcircuits reflects the long-distance axonal targets of principal neurons.
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Acknowledgements
We thank R. Zhu and M. Cid for technical assistance and I. Sears-Kraxberger and H.S. Keirstead for their generous support with electron microscopy. This work was supported by the US National Institutes of Health grant NS35915 (I.S.) and the American Epilepsy Society (S.Y.L.).
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C.V., S.Y.L. and I.S. designed the experiments. C.V. and S.Y.L. performed the experiments and analyzed the data. C.V., S.Y.L. and I.S. wrote the paper.
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Varga, C., Lee, S. & Soltesz, I. Target-selective GABAergic control of entorhinal cortex output. Nat Neurosci 13, 822–824 (2010). https://doi.org/10.1038/nn.2570
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DOI: https://doi.org/10.1038/nn.2570
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