A new study shows that a candidate schizophrenia pathway, neuregulin-1–ErbB4 signaling, inhibits Src-mediated enhancement of synaptic N-methyl-D-aspartate receptor (NMDAR) function (pages 470–478). These results suggest that Src can have a pivotal role in NMDAR hypofunction in schizophrenia and thus might have potential therapeutic implications for this complex neuropsychiatric disorder.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Rent or buy this article
Prices vary by article type
from$1.95
to$39.95
Prices may be subject to local taxes which are calculated during checkout
References
Kantrowitz, J.T. & Javitt, D.C. Brain Res. Bull. 83, 108–121 (2010).
Harrison, P.J. & Weinberger, D.R. Mol. Psychiatry 10, 40–68 (2005).
Stefansson, H., Steinthorsdottir, V., Thorgeirsson, T.E., Gulcher, J.R. & Stefansson, K. Ann. Med. 36, 62–71 (2004).
Chong, V.Z. et al. Schizophr. Res. 100, 270–280 (2008).
Law, A.J. et al. Proc. Natl. Acad. Sci. USA 103, 6747–6752 (2006).
Hahn, C.G. et al. Nat. Med. 12, 824–828 (2006).
Pitcher, G.M. et al. Nat. Med. 17, 470–478 (2011).
Salter, M.W. & Kalia, L.V. Nat. Rev. Neurosci. 5, 317–328 (2004).
Anton, E.S. et al. Nat. Neurosci. 7, 1319–1328 (2004).
Li, B., Woo, R.S., Mei, L. & Malinow, R. Neuron 54, 583–597 (2007).
Kwon, O.B. et al. Proc. Natl. Acad. Sci. USA 105, 15587–15592 (2008).
Wen, L. et al. Proc. Natl. Acad. Sci. USA 107, 1211–1216 (2010).
Role, L.W. & Talmage, D.A. Nature 448, 263–265 (2007).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Hahn, CG. A Src link in schizophrenia. Nat Med 17, 425–427 (2011). https://doi.org/10.1038/nm0411-425
Published:
Issue Date:
DOI: https://doi.org/10.1038/nm0411-425
This article is cited by
-
Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches
Journal of Neural Transmission (2014)
-
Neuregulin-1 signalling and antipsychotic treatment
Psychopharmacology (2013)