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A Src link in schizophrenia

A new study shows that a candidate schizophrenia pathway, neuregulin-1–ErbB4 signaling, inhibits Src-mediated enhancement of synaptic N-methyl-D-aspartate receptor (NMDAR) function (pages 470–478). These results suggest that Src can have a pivotal role in NMDAR hypofunction in schizophrenia and thus might have potential therapeutic implications for this complex neuropsychiatric disorder.

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Figure 1: Src mediates NMDAR hypofunction induced by enhanced NRG1-ErbB4 signaling in schizophrenia.

References

  1. Kantrowitz, J.T. & Javitt, D.C. Brain Res. Bull. 83, 108–121 (2010).

    Article  CAS  Google Scholar 

  2. Harrison, P.J. & Weinberger, D.R. Mol. Psychiatry 10, 40–68 (2005).

    Article  CAS  Google Scholar 

  3. Stefansson, H., Steinthorsdottir, V., Thorgeirsson, T.E., Gulcher, J.R. & Stefansson, K. Ann. Med. 36, 62–71 (2004).

    Article  CAS  Google Scholar 

  4. Chong, V.Z. et al. Schizophr. Res. 100, 270–280 (2008).

    Article  Google Scholar 

  5. Law, A.J. et al. Proc. Natl. Acad. Sci. USA 103, 6747–6752 (2006).

    Article  CAS  Google Scholar 

  6. Hahn, C.G. et al. Nat. Med. 12, 824–828 (2006).

    Article  CAS  Google Scholar 

  7. Pitcher, G.M. et al. Nat. Med. 17, 470–478 (2011).

    Article  CAS  Google Scholar 

  8. Salter, M.W. & Kalia, L.V. Nat. Rev. Neurosci. 5, 317–328 (2004).

    Article  CAS  Google Scholar 

  9. Anton, E.S. et al. Nat. Neurosci. 7, 1319–1328 (2004).

    Article  CAS  Google Scholar 

  10. Li, B., Woo, R.S., Mei, L. & Malinow, R. Neuron 54, 583–597 (2007).

    Article  CAS  Google Scholar 

  11. Kwon, O.B. et al. Proc. Natl. Acad. Sci. USA 105, 15587–15592 (2008).

    Article  CAS  Google Scholar 

  12. Wen, L. et al. Proc. Natl. Acad. Sci. USA 107, 1211–1216 (2010).

    Article  CAS  Google Scholar 

  13. Role, L.W. & Talmage, D.A. Nature 448, 263–265 (2007).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Chang-Gyu Hahn.

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Hahn, CG. A Src link in schizophrenia. Nat Med 17, 425–427 (2011). https://doi.org/10.1038/nm0411-425

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