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Tissue specific expression of FMR–1 provides evidence for a functional role in fragile X syndrome

Nature Genetics volume 3, pages 36–43 (1993)Cite this article

A Correction to this article was published on 01 November 1993

Abstract

We have performed mRNA in situ hybridization studies and northern blot analysis in the mouse and human, respectively, to determine the normal gene expression patterns of FMR–1. Expression in the adult mouse was localized to several regions of the brain and the tubules of the testes, which are two of the major organs affected in fragile X syndrome. Universal and very strong expression was observed in early mouse embryos, with differentially decreasing expression during subsequent stages of embryonic development. The early embryonic onset and tissue specificity of FMR–1 gene expression is consistent with involvement in the fragile X phenotype, and also suggests additional organ systems in which clinical manifestations of reduced FMR–1 gene expression may occur.

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Authors and Affiliations

  1. Center for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Heather L. Hinds, David E. Housman & Martin Schalling

  2. Institute for Molecular Genetics, Human Genome Center, Howard Hughes Medical Institute and the Baylor College of Medicine, Houston, Texas, 77030, USA

    James S. Sutcliffe & David L. Nelson

  3. Departments of Biochemistry and Pediatrics, Howard Hughes Medical Institute, Emory University School of Medicine, Atlanta, Georgia, 30322, USA

    Claude T. Ashley, James S. Sutcliffe & Stephen T. Warren

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  1. Heather L. Hinds
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  7. Martin Schalling
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Hinds, H., Ashley, C., Sutcliffe, J. et al. Tissue specific expression of FMR–1 provides evidence for a functional role in fragile X syndrome. Nat Genet 3, 36–43 (1993). https://doi.org/10.1038/ng0193-36

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