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Genealogies of mouse inbred strains

Nature Genetics volume 24, pages 23–25 (2000)Cite this article

Abstract

The mouse is a prime organism of choice for modelling human disease. Over 450 inbred strains of mice have been described, providing a wealth of different genotypes and phenotypes for genetic and other studies. As new strains are generated and others become extinct, it is useful to review periodically what strains are available and how they are related to each other, particularly in the light of available DNA polymorphism data from microsatellite and other markers. We describe the origins and relationships of inbred mouse strains, 90 years after the generation of the first inbred strain. Given the large collection of inbred strains available, and that published information on these strains is incomplete, we propose that all genealogical and genetic data on inbred strains be submitted to a common electronic database to ensure this valuable information resource is preserved and used efficiently.

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Acknowledgements

We thank all members of the mouse community who supplied information on inbred strains, particularly, J. Staats, P.W. Lane, E.M. Eicher, R. Elliot, J. Forejt, D. Juriloff, E. Leiter, C. Linder, T. Monique, K. Moore, L. Morel, O. Niwa, G. Raisman, D. Tabaczynski and G. Wolff. J.A.B., S.L. and M.H. are supported by the UK Medical Research Council; J.T.E. and M.L.-P. are supported by NIH grant HG00330.

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Authors and Affiliations

  1. MRC Prion Unit, Imperial College School of Medicine (St. Mary's), Norfolk Place, London, UK

    Jon A. Beck, Sarah Lloyd & Majid Hafezparast

  2. Department of Neurogenetics, Imperial College School of Medicine (St. Mary's), Norfolk Place, London , UK

    Jon A. Beck, Sarah Lloyd, Majid Hafezparast & Elizabeth M.C. Fisher

  3. The Jackson Laboratory, Bar Harbor, Maine, USA

    Moyha Lennon-Pierce & Janan T. Eppig

  4. MRC Toxicology Unit, Hodgkin Building, University of Leicester, Leicester,, UK

    Michael F.W. Festing

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  1. Jon A. Beck
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Correspondence to Elizabeth M.C. Fisher.

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Beck, J., Lloyd, S., Hafezparast, M. et al. Genealogies of mouse inbred strains. Nat Genet 24, 23–25 (2000). https://doi.org/10.1038/71641

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