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Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila

A Corrigendum to this article was published on 21 April 1988

Abstract

At least four probable components of potassium channels are encoded at the Drosophila Shaker locus, by a family of alternatively spliced transcripts. Alternative splicing may provide one mechanism of generating the remarkable diversity of potassium channels.

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References

  1. Hodgkin, A. L. & Huxley, A. F. J. Physiol., Lond. 117, 500–544 (1952).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Byerly, L. & Masuda, M. O. J. Physiol., Lond. 288, 263–284 (1979).

    CAS  PubMed  PubMed Central  Google Scholar 

  3. Meech, R. W. & Standen, N. B. J. Physiol., Lond. 249, 211–239 (1975).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Adams, P. R., Brown, D. A. & Constanti, A. J. Physiol., Lond. 330, 537–572 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Grega, D. S., Werz, M. A. & MacDonald, R. L. Science 235, 345–348 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  6. Dunlap, K., Holz, G. G. & Rane, S. G. Trends Neurosci. 10, 241–244 (1987).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Piomelli, D. et al. Nature 328, 38–43 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  8. Hille, B. Ionic Channels of Excitable Membranes (Sinauer, Sunderland, Massachusetts, 1984).

    Google Scholar 

  9. Belardetti, F., Schacher, S. & Siegelbaum, S. A. J. Physiol., Lond. 374, 289–313 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Grissmer, S. J. Physiol., Lond. 381, 119–134 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Papazian, D. M., Schwarz, T. L., Tempel, B. L., Jan, Y. N. & Jan, L. Y. Science 237, 749–753 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Tempel, B. L., Papazian, D. M., Schwarz, T. L., Jan, Y. N. & Jan, L. Y. Science 237, 770–775 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  13. Kamb, A., Iverson, L. E. & Tanouye, M. A. Cell 50, 405–413 (1987).

    Article  CAS  PubMed  Google Scholar 

  14. Baumann, A. et al. EMBO J. 6, 3419–3429 (1987).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Hagiwara, S. & Siato, N. J. Physiol., Lond. 148, 161–179 (1959).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Connor, J. A. & Stevens, C. F. J. Physiol., Lond. 213, 21–30 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Ito, I. & Maeno, T. J. Physiol., Lond. 373, 115–127 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Cassell, J. F., Clark, A. L. & McLachlan, E. M. J. Physiol., Lond. 372, 457–483 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Kawa, K. J. Physiol., Lond. 385, 189–205 (1987).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Connor, J. A. Fedn Proc. 37, 2139–2145 (1978).

    CAS  Google Scholar 

  21. Salkoff, L. Cold Spring Harb. Symp. quant. Biol. 48, 221–232 (1984).

    Article  Google Scholar 

  22. Connor, J. A. & Stevens, C. F. J. Physiol., Lond. 213, 31–53 (1971).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  23. Tanouye, M. A., Ferrus, A. & Fujita, S. C. Proc. natn. Acad. Sci. U.S.A. 78, 6548–6552 (1981).

    Article  ADS  CAS  Google Scholar 

  24. Jan, Y. N., Jan, L. Y. & Dennis, M. J. Proc. R. Soc. B198, 87–108 (1977).

    ADS  Google Scholar 

  25. Alkon, D. L., Lederhendler, I. & Shoukimas, J. L. Science 215, 693–695 (1982).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Timpe, L. C. & Jan, L. Y. J. Neurosci. 7, 1307–1317 (1987).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Wu, C. F. & Haugland, F. J. Neurosci. 10, 2626–2640 (1985).

    Article  Google Scholar 

  28. Noda, M. et al. Nature 312, 121–127 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  29. Tanabe, T. et al. Nature 328, 313–318 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  30. Timpe, L. C. et al. Nature 331, 143–145 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  31. Mount, S. M. Nucleic Acids Res. 10, 459–472 (1982).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Grenningloh, G. et al. Nature 328, 215–220 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  33. Greenblatt, R. E., Blatt, Y. & Montal, M. FEBS Lett. 193, 125–134 (1985).

    Article  CAS  PubMed  Google Scholar 

  34. Guy, H. R. & Seetharamulu, P. Proc. natn. Acad. Sci. U.S.A. 83, 508–512 (1986).

    Article  ADS  CAS  Google Scholar 

  35. Noda, M. et al. Nature 320, 188–192 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

  36. Catterall, W. A. A. Rev. Biochem. 55, 953–985 (1986).

    Article  CAS  Google Scholar 

  37. Krebs, E. G. & Beavo, J. A. A. Rev. Biochem. 48, 923–958 (1979).

    Article  CAS  Google Scholar 

  38. Wharton, K. A., Yedvobnick, B., Finnerty, V. G. & Artavanis-Tsakonas, S. Cell 40, 55–62 (1985).

    Article  CAS  PubMed  Google Scholar 

  39. Leff, S. E., Rosenfeld, M. G. & Evans, R. M. A. Rev. Biochem. 55, 1091–1117 (1986).

    Article  CAS  Google Scholar 

  40. Jorgensen, E. M. & Garber, R. L. Genes Dev. 1, 544–555 (1987).

    Article  CAS  PubMed  Google Scholar 

  41. Noda, M. et al. Nature 302, 528–532 (1983).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Solc, C. K., Zagotta, W. N. & Aldrich, R. W. Science 236, 1094–1098 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  43. Ganetzky, B. & Wu, C. F. A. Rev. Genet. 20, 13–44 (1986).

    Article  CAS  Google Scholar 

  44. Itoh, N., Salvaterra, P. & Itakura, K. Drosoph. Inf. Serv. 61, 89 (1985).

    Google Scholar 

  45. Sanger, F. et al. Proc. natn. Acad. Sci. U.S.A. 74, 5463–5467 (1977).

    Article  ADS  CAS  Google Scholar 

  46. Chen, E. Y. & Seeburg, P. H. DNA 4, 165–170 (1985).

    Article  CAS  PubMed  Google Scholar 

  47. Hafen, E., Basler, K., Edstroem, J. E. & Rubin, G. M. Science 236, 55–63 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  48. Banerjee, U., Renfranz, P. J., Pollock, J. A. & Benzer, S. Cell 49, 281–291 (1987).

    Article  CAS  PubMed  Google Scholar 

  49. Church, G. M. & Gilbert, W. Proc. natn. Acad. Sci. U.S.A. 81, 1991–1995 (1984).

    Article  ADS  CAS  Google Scholar 

  50. Sobel, E. & Martinez, H. M. Nucleic Acids Res. 14, 363–374 (1985).

    Article  Google Scholar 

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Schwarz, T., Tempel, B., Papazian, D. et al. Multiple potassium–channel components are produced by alternative splicing at the Shaker locus in Drosophila. Nature 331, 137–142 (1988). https://doi.org/10.1038/331137a0

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