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Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor

Nature volume 326, pages 353–358 (1987)Cite this article

Abstract

We show that nerve growth factor (NGF) synthesis in developing skin begins with sensory innervation and that sensory neurons do not express NGF receptors until their fibres reach their cutaneous targets. Both cutaneous epithelium and mesenchyme synthesize NGF, the concentration of messenger RNAfor NGF being higher in the more densely innervated epithelium.

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Authors and Affiliations

  1. Department of Anatomy, St George's Hospital Medical School, Cranmer Terrace, Tooting, London, SW17 ORE, UK

    Alun M. Davies

  2. Department of Neurochemistry, Max-Planck-Institute for Psychiatry, 8033 Planegg-Martinsried, Munchen, FRG

    Christine Bandtlow, Rolf Heumann, Sigrun Korsching, Hermann Rohrer & Hans Thoenen

Authors
  1. Alun M. Davies
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  2. Christine Bandtlow
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  3. Rolf Heumann
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  4. Sigrun Korsching
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  5. Hermann Rohrer
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  6. Hans Thoenen
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Davies, A., Bandtlow, C., Heumann, R. et al. Timing and site of nerve growth factor synthesis in developing skin in relation to innervation and expression of the receptor . Nature 326, 353–358 (1987). https://doi.org/10.1038/326353a0

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