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Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A

Nature volume 320, pages 134–139 (1986)Cite this article

Abstract

We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.

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Authors and Affiliations

  1. Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, Unité 184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Faculté de Médecine, 11 rue Humann, 67085, Strasbourg Cédex, France

    Stephen Green, Philippe Walter, Vijay Kumar, Andrée Krust, Jean-Marc Bornert & Pierre Chambon

  2. European Molecular Biology Laboratory, Postfach 10.2209, Meyerhofstrasse 1, 6900, Heidelberg, FRG

    Patrick Argos

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  1. Stephen Green
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  2. Philippe Walter
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Green, S., Walter, P., Kumar, V. et al. Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature 320, 134–139 (1986). https://doi.org/10.1038/320134a0

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