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Magnocellular axons in passage through the median eminence release vasopressin

Abstract

Vasopressin (arginine vasopressin, AVP) is present in two types of nerve fibres in the median eminence (ME)1–3. First, it is found in nerve terminals that originate in the parvicellular neurones of the hypothalamic paraventricular nucleus (PVN) and abut on the pericapillary space surrounding the fenestrated capillaries of the primary pituitary portal plexus in the external zone (EZ) of the ME. These neurones also synthesize corticotropin-releasing factor (CRF)4–6, which acts synergetically with vasopressin to stimulate release of adrenocorticotropin (ACTH) from the pituitary gland (see ref. 7). Second, vasopressinergic axons of the magnocellular neurosecretory system pass through the internal zone (IZ) of the ME to terminate in the neurohaemal contact zone of the neurohy-pophysis. The involvement of vasopressinergic magnocellular neurones in the control of ACTH secretion is much debated7. Of particular interest in this context is the origin of the vasopressin found in pituitary portal blood1,8,9. Although it has been demonstrated that vasopressin and CRF are present in the same neurosecretory granules of EZ fibres3, parallel determinations of vasopressin and CRF in pituitary portal blood have shown alterations of the concentration of vasopressin without a concomitant change in that of CRF8,9. Such a dissociation suggests that either differential release of vasopressin and CRF can occur from a single population of nerve endings, or there are fibres in the pituitary-stalk ME which release vasopressin but not CRF. Here we present evidence for the latter. Our results indicate that stimuli causing depolarization of the axonal membrane in vitro elicit release of vasopressin from nerve fibres in the external and internal zones of the ME.

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References

  1. Zimmerman, E. A. et al. Ann. N.Y. Acad. Sci. 297, 405–417 (1977).

    Article  ADS  CAS  Google Scholar 

  2. Burlei, A., Chateau-Chapler, M. & Dreyfuss, F. Neuroendocrinology of Vasopressin, Corticoliberin and Opiomelanocortins (eds Baertschi, A. J. & Dreyfuss, J. J.) 95–106 (Academic, London, 1982).

    Google Scholar 

  3. Whitnall, M. H., Mezey, E. & Gainer, H. Nature 317, 248–250 (1985).

    Article  ADS  CAS  Google Scholar 

  4. Kiss, J. Z., Mezey, E. & Skirboll, L. Proc. natn. Acad. Sci. U.S.A. 81, 1854–1858 (1984).

    Article  ADS  CAS  Google Scholar 

  5. Sawchenko, P. E., Swanson, L. W. & Vale, W. W. Proc. natn. Acad. Sci. U.S.A. 81, 1883–1887 (1984).

    Article  ADS  CAS  Google Scholar 

  6. Tramu, G., Croix, G. & Pillez, A. Neuroendocrinology 37, 467–469 (1983).

    Article  CAS  Google Scholar 

  7. Makara, G. B., Antoni, F. A., Stark, E. & Karteszi, M. Perspectives in Neuroendocrinology Vol. 3 (eds Müller, E. E. & McLeod, R. M.) 71–119 (Elsevier, Amsterdam, 1984).

    Book  Google Scholar 

  8. Gibbs, D. M. Fedn Proc. 44, 203–206 (1985).

    CAS  Google Scholar 

  9. Plotsky, P. M. Fedn Proc. 44, 207–213 (1985).

    CAS  Google Scholar 

  10. Holmes, M. C., Antoni, F. A., Catt, K. J. & Aguilera, G. Neuroendocrinology (in the press).

  11. Bhattacharya, A. N. & Marks, B. H. J. Pharmac. exp. Ther. 165, 108–116 (1969).

    CAS  Google Scholar 

  12. Seybold, V., Eide, R. & Hokfelt, T. Endocrinology 108, 1803–1809 (1981).

    Article  CAS  Google Scholar 

  13. Bugnon, C. et al. J. Steroid Biochem. 20, 183–195 (1984).

    Article  CAS  Google Scholar 

  14. Rhodes, C. H., Morrell, J. L. & Pfaff, D. W. J. comp. Neurol. 198, 45–64 (1984).

    Article  Google Scholar 

  15. Antoni, F. A., Holmes, M. C. & Kiss, J. Z. Endocrinology 117, 1293–1299 (1985).

    Article  CAS  Google Scholar 

  16. Ixart, G. et al. Neuroendocrinology 35, 270–276 (1982).

    Article  CAS  Google Scholar 

  17. Makara, G. B. Adv. physiol. Sci. 14, 31–44 (1981).

    CAS  Google Scholar 

  18. Antoni, F. A., Makara, G. B. & Rappay, Gy. J. Endocr. 91, 415–423 (1981).

    Article  CAS  Google Scholar 

  19. Marchbanks, R. M. Biochem. J. 104, 148–157 (1967).

    Article  CAS  Google Scholar 

  20. Seitz, H. M. Z. Zellforsch. Mikrosk. Anat. 67, 351–366 (1965).

    Article  CAS  Google Scholar 

  21. Page, R. B. & Dovey-Hartman, J. J. comp. Neurol. 226, 274–288 (1984).

    Article  CAS  Google Scholar 

  22. Grafstein, B. & Forman, D. S. Physiol. Rev. 60, 1167–1283 (1980).

    Article  CAS  Google Scholar 

  23. Reichardt, L. F. & Kelly, R. B. A. Rev. Biochem. 52, 871–926 (1983).

    Article  CAS  Google Scholar 

  24. Gillies, G. & Lowry, P. J. Frontiers in Neuroendocrinology. Vol. 7 (eds Ganong, W. F. & Martini, L.) 45–75 (Raven, New York, 1981).

    Google Scholar 

  25. Russell, J. T., Brownstein, M. J. & Gainer, H. Brain Res. 201, 227–232 (1980).

    Article  CAS  Google Scholar 

  26. Knepel, W., Nutto, D., Meyer, D. K. & Vlaskovska, M. Neurosci. Lett. 48, 321–326 (1984).

    Article  CAS  Google Scholar 

  27. Andersson, E. Science 152, 379–380 (1966).

    Article  ADS  Google Scholar 

  28. Green, J. D. & Harris, G. W. J. Endocr. 5, 136–145 (1947).

    Article  CAS  Google Scholar 

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Holmes, M., Antoni, F., Aguilera, G. et al. Magnocellular axons in passage through the median eminence release vasopressin. Nature 319, 326–329 (1986). https://doi.org/10.1038/319326a0

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