Abstract
THE C-terminal region of lipotropin, named C fragment1, has been found as an intact polypeptide in the pituitary gland2 and the C fragment is also released from lipotropin by mild digestion with trypsin in vitro1. These data suggest that the C fragment of lipotropin might be elaborated in vivo in order to perform a physiological function.
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References
Bradbury, A. F., Smyth, D. G., and Snell, C. R., in The Peptide Hormones: Molecular and Cellular Aspects, CIBA Found. Svmp. No. 41, 61–75 (Churchill, London, 1976).
Bradbury, A. F., Smyth, D. G., and Snell, C. R., in Peptides, Chemistry, Structure and Biology, Proc., IV American Peptide Symp. (edit. by Meienhofer, J.), 61–75 (Ann Arbor Science Inc., Ann Arbor, 1975).
Cox, B. M., Opheim, K. E., Teschemacher, H., and Goldstein, A., Life Sci., 16, 1777–1782 (1975).
Teschemacher, H., Opheim, K. E., Cox, B. M., and Goldstein, A., Life Sci., 16, 1771–1776 (1975).
Terenius, L., Wahlström, A., Actapharmac. toxicol., Suppl. 1, 35 (1974).
Hughes, J., Brain Res., 88, 295–308 (1975).
Pasternak, G. W., Goodman, R., and Snyder, S. H., Life Sci., 16, 1765–1769 (1975).
Hughes, J., et al., Nature, 258, 577–579 (1975).
Li, C. H., Barnafi, L., Chretien, M., and Chung, D., Nature, 208, 1093–1094 (1965).
Stark, G. R., and Smyth, D. G., J. biol. Chem., 238, 214–216 (1963).
Ambler, R. P., in Methods in Enzymology, II (edit. by Hirs, C. H. W.), 436–445 (Academic Press, New York, 1967).
Spackman, D. M., Stein, W. H., Moore, S., Analyt. Chem., 30, 1190–1206 (1958).
Merrifield, R. B., J. Am. chem. Soc., 85, 2149–2154 (1963).
Creese, I., and Snyder, S. H., J. pharmac. exp. Ther., 194, 205–219 (1975).
Bradbury, A. F., Smyth, D. G., and Snell, C. R., Biochem. biophys. Res. Commun. (in the press).
Pert, C. B., Pasternak, G. W., and Snyder, S. H., Science, 182, 1359–1361 (1973).
Pert, C. B., and Snyder, S. H., Mol. Pharmac., 10, 868–879 (1974).
Simon, E. J., Hiller, J. M., Groth, J., and Edelman, I., J. Pharmac. exp. Ther., 192, 531–537 (1975).
Snyder, S. H., Nature, 257, 185–189 (1975).
Bradbury, A. F., Smyth, D. G., and Snell, C. R., Nature, 260, 165–166 (1976).
Feldberg, W. S., and Smyth, D. G., J. Physiol. (in the press).
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BRADBURY, A., SMYTH, D., SNELL, C. et al. C fragment of lipotropin has a high affinity for brain opiate receptors. Nature 260, 793–795 (1976). https://doi.org/10.1038/260793a0
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DOI: https://doi.org/10.1038/260793a0
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