Abstract
INHIBITORS of macromolecular synthesis have been used extensively for studies of memory storage. The amnesic effects of two inhibitors of protein synthesis, acetoxy-cycloheximide and cycloheximide, have been attributed to specific interference with the synthesis of protein required for formation of long-term memory1–4. The effects of actinomycin-D, an inhibitor of DNA-dependent RNA synthesis, have been particularly difficult to interpret because doses sufficient to produce marked inhibition of cerebral RNA synthesis produce fairly rapid onset of irreversible systemic toxicity5,6. Even much smaller doses produce localized chromatolysis7 and may lead to death. Studies with rodents injected before learning show that marked inhibition of RNA synthesis does not interfere with retention for a few hours after injection5,6,8, but the marked toxicity of this drug has limited its usefulness in studies of the participation of cerebral RNA synthesis in long term memory.
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References
Barondes, S. H., and Cohen, H. D., Proc. US Nat. Acad. Sci., 58, 157 (1967).
Cohen, H. D., and Barondes, S. H., Nature, 218, 271 (1968).
Cohen, H. D., and Barondes, S. H., Comm. Behav. Biol., 1, 337 (1968).
Agranoff, B. W., Davis, R. E., and Brink, J. J., Brain Res., 1, 303 (1966).
Barondes, S. H., and Jarvik, M. E., J. Neurochem., 11, 187 (1964).
Cohen, H. D., and Barondes, S. H., J. Neurochem., 13, 207 (1966).
Nakajima, S., J. Comp. Physiol. Psychol., 67, 457 (1969).
Goldsmith, L., J. Comp. Physiol. Psychol., 63, 126 (1967).
Agranoff, B. W., Davis, R. E., Casola, L., and Lim, R., Science, 158, 1600 (1967).
Booth, D. A., Psychol. Bull., 68, 149 (1967).
Agranoff, B. W., Davis, R. E., and Brink, J. J., Proc. US Nat. Acad. Sci., 54, 788 (1965).
Davis, R. E., Bright, P. J., and Agranoff, B. W., J. Comp. Physiol. Psychol., 60, 162 (1965).
Flexner, J. B., Flexner, L. B., and Stellar, E., Science, 141, 57 (1963).
Rosenbaum, M., Cohen, H. D., and Barondes, S. H., Comm. Behav. Biol., 2, 47 (1968).
Deutsch, J. A., Hamburg, M. D., and Dahl, H., Science, 151, 221 (1966).
Deutsch, J. A., and Rocklin, K. W., Nature, 216, 89 (1967).
Wiener, N., and Deutsch, J. A., J. Comp. Physiol. Psychol., 66, 613 (1968).
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SQUIRE, L., BARONDES, S. Actinomycin-D: Effects on Memory at Different Times after Training. Nature 225, 649–650 (1970). https://doi.org/10.1038/225649a0
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DOI: https://doi.org/10.1038/225649a0
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