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Neurobiological features of binge eating disorder

Published online by Cambridge University Press:  04 November 2015

Iris M. Balodis*
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Carlos M. Grilo
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA Department of Psychology, Yale University School of Medicine, New Haven, Connecticut, USA CASAColumbia, Yale University School of Medicine, New Haven, Connecticut, USA
Marc N. Potenza
Affiliation:
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA CASAColumbia, Yale University School of Medicine, New Haven, Connecticut, USA Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
*
*Address for correspondence: Iris M. Balodis, Department of Psychiatry, Yale University, 1 Church Street, New Haven, CT 06511, USA. (Email: iris.balodis@yale.edu)

Abstract

Biobehavioral features associated with binge-eating disorder (BED) have been investigated; however, few systematic reviews to date have described neuroimaging findings from studies of BED. Emerging functional and structural studies support BED as having unique and overlapping neural features as compared with other disorders. Neuroimaging studies provide evidence linking heightened responses to palatable food cues with prefrontal areas, particularly the orbitofrontal cortex (OFC), with specific relationships to hunger and reward-sensitivity measures. While few studies to date have investigated non-food-cue responses; these suggest a generalized hypofunctioning in frontostriatal areas during reward and inhibitory control processes. Early studies applying neuroimaging to treatment efforts suggest that targeting neural function underlying motivational processes may prove important in the treatment of BED.

Type
Review Articles
Copyright
Copyright © Cambridge University Press 2015 

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Footnotes

This was supported by P20 DA027844, K24 DK070052, CASAColumbia and the National Center for Responsible Gaming.

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