Elsevier

Genomics

Volume 96, Issue 2, August 2010, Pages 82-91
Genomics

Comparative gene expression analysis in mouse models for multiple sclerosis, Alzheimer's disease and stroke for identifying commonly regulated and disease-specific gene changes

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Abstract

The brain responds to injury and infection by activating innate defense and tissue repair mechanisms. Working upon the hypothesis that the brain defense response involves common genes and pathways across diverse pathologies, we analysed global gene expression in brain from mouse models representing three major central nervous system disorders, cerebral stroke, multiple sclerosis and Alzheimer's disease compared to normal brain using DNA microarray expression profiling. A comparison of dysregulated genes across disease models revealed common genes and pathways including key components of estrogen and TGF-β signaling pathways that have been associated with neuroprotection as well as a neurodegeneration mediator, TRPM7. Further, for each disease model, we discovered collections of differentially expressed genes that provide novel insight into the individual pathology and its associated mechanisms. Our data provide a resource for exploring the complex molecular mechanisms that underlie brain neurodegeneration and a new approach for identifying generic and disease-specific targets for therapy.

Abbreviations

EAE
experimental autoimmune encephalomyelitis
CNS
central nervous system
pMCAO
permanent middle cerebral artery occlusion
AD
Alzheimer's disease
MS
multiple sclerosis
CS
cerebral stroke

Keywords

cDNA microarrays
Brain inflammation
Cerebral stroke
Alzheimer's disease
Systems biology
Gene expression profiling

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