Elsevier

Developmental Biology

Volume 302, Issue 2, 15 February 2007, Pages 367-375
Developmental Biology

Review
Functions of BarH transcription factors during embryonic development

https://doi.org/10.1016/j.ydbio.2006.10.008Get rights and content
Under an Elsevier user license
open archive

Abstract

This paper reviews the developmental role of a group of homeobox-containing genes firstly described in the early nineties as critical factors regulating eye development in Drosophila. These genes received the name of BarH due to the Drosophila “Bar” mutant phenotype and, since then, vertebrate homologues (named BarH-like or Barhl) have been described in a number of species of fish, amphibians and mammals. During embryonic development, BarH/Barhl are expressed primarily in the central nervous system where they play essential roles in decisions of cell fate, migration and survival. Transcriptional regulation mediated by these proteins involves either repression or activation mechanisms. In Drosophila, BarH is involved in morphogenesis and fate determination of the eye and external sensory organs, in regional prepatterning of the notum, and in formation and specification of distal leg segments. Vertebrate Barhl shares some functional properties with the fly counterparts, such as the ability to interact with basic helix–loop–helix (bHLH) proneural proteins, and plays crucial roles during cell type specification within the retina, acquisition of commissural neuron identity in the spinal cord, migration of cerebellar cells, and in cell survival within the neural plate, cochlea and cerebellum.

Keywords

Homeodomain
BarH
Barhl
FIL domains
Central nervous system
Eye
Development
Vertebrates
Drosophila

Cited by (0)