Elsevier

Vision Research

Volume 50, Issue 21, 12 October 2010, Pages 2176-2187
Vision Research

ERG changes in albino and pigmented mice after optic nerve transection

https://doi.org/10.1016/j.visres.2010.08.014Get rights and content
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Abstract

Optic nerve transection (ONT) triggers retinal ganglion cell (RGC) death. By using this paradigm, we have analyzed for the first time in adult albino and pigmented mice, the effects of ONT in the scotopic threshold response (STR) components (negative and positive) of the full-field electroretinogram. Two weeks after ONT, when in pigmented mice approximately 18% of the RGC population survive, the STR-implicit time decreased and the p and nSTR waves diminished approximately to 40% or 55%, in albino or pigmented, respectively, with respect to the values recorded from the non-operated contralateral eyes. These changes were maintained up to 12 weeks post-ONT, demonstrating that the ERG–STR is a useful parameter to monitor RGC functionality in adult mice.

Research highlights

► Effects of optic nerve transection on the dark adapted ERG of mice. ► Persistent changes in the n- and pSTR amplitude following axotomy. ► Persistent changes in the n- and pSTR implicit time following axotomy. ► ERG–STR is a useful parameter to monitor RGC functionality in adult mice.

Keywords

Electroretinogram (ERG)
Scotopic threshold response (STR)
Optic nerve transection (ONT)
Axotomy
Retinal ganglion cells (RGCs)
Adult albino and pigmented mice
Neuronal degeneration
Retina

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These authors contributed equally to this work.