It is not “either/or”: Activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
Section snippets
Conclusions
The studies reviewed here show that there is no simple relationship between smoking and nAChR activation or desensitization. Rather, coordinated activation and desensitization of a number of different nAChRs on different neuronal subtypes likely occurs in response to nicotine administration through smoking. Neither desensitization alone nor activation alone is sufficient to explain the behavioral consequences of nicotine intake, just as nicotine reward alone is not sufficient to explain smoking
Acknowledgements
This work was supported by NIH grants MH77681, DA13334/AA15632, DA14241, DA10455 and DA00436.
References (170)
- et al.
Nicotine dependence and tolerance in man: pharmacokinetic and pharmacodynamic investigations
Prog. Brain Res.
(1989) - et al.
High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation
Biol. Psychiatry
(2004) - et al.
Brain choline in depression: in vivo detection of potential pharmacodynamic effects of antidepressant therapy using hydrogen localized spectroscopy
Prog. Neuro-Psychopharm. Biol. Psych.
(1994) - et al.
Does amygdalar perfusion correlate with antidepressant response to partial sleep deprivation in major depression?
Psychiatry Res.
(2006) - et al.
Self-administered nicotine activates the mesolimbic dopamine system through the ventral tegmental area
Brain Res.
(1994) - et al.
Nicotine enhances intracellular nicotinic receptor maturation: a novel mechanism of neural plasticity?
J. Physiol.
(2006) - et al.
A neuronal nicotinic acetylcholine receptor subunit (α7) is developmentally regulated and forms homo-oligomeric channel blocked by α-Bungarotoxin
Neuron
(1990) - et al.
Alpha5, alpha3 and non-alpha3, three clustered avian genes encoding neuronal acetylcholine receptor related subunits
J. Biol. Chem.
(1990) - et al.
Exocytic trafficking is required for nicotine-induced upregulation of alpha4beta2 nicotinic acetylcholine receptors
J. Biol. Chem.
(2005) - et al.
Differential prevalence of cigarette smoking in patients with schizophrenic vs. mood disorders
Schizophr. Res.
(1998)
Antidepressant effect of ingested nicotine in female rats of Flinders resistant and sensitive lines
Physiol. Behav.
(1999)
Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders
Curr. Opin. Neurobiol.
(2001)
Neural plasticity to stress and antidepressant treatment
Biol. Psychiatry
(1999)
Smoking, nicotine and psychiatric disorders: evidence for therapeutic role, controversies and implications for future research
Med. Hypoth.
(1999)
The functional diversity of the neuronal nicotinic acetylcholine receptors is increased by a novel subunit: beta 4
Neuron
(1989)
Behavioral and neural consequences of prenatal exposure to nicotine
J. Am. Acad. Child. Adol. Psychiatry
(2001)
Neuronal nicotinic receptors: molecular organization and regulations
Neuropharmacology
(1995)
A preliminary study of the effects of cigarette smoking on prepulse inhibition in schizophrenia: involvement of nicotinic receptor mechanisms
Schizophr. Res.
(2006)
Effects of smoking abstinence on visuospatial working memory function in schizophrenia
Neuropsychopharmacology
(2002)
Desensitization of nicotinic ACh receptors: shaping cholinergic signaling
Trends Neurosci.
(2005)
Brain nicotinic acetylcholine receptors: native subtypes and their relevance
Trends Pharmacol. Sci.
(2006)
Higher levels of nicotine in arterial rather than venous blood after cigarette smoking
Drug Alcohol Depend.
(1993)
A cholinergic-adrenergic hypothesis of mania and depression
Lancet
(1972)
beta2-Subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration
Neuropharmacology
(2004)
The pedunculopontine tegmental nucleus and the role of cholinergic neurons in nicotine self-administration in the rat: a correlative neuroanatomical and behavioral study
Neuroscience
(2000)
The nicotinic antagonist mecamylamine preferentially inhibits cocaine vs. food self-administration in rats
Physiol. Behav.
(2000)
Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
Neuron
(2002)
Long-term potentiation of excitatory inputs to brain reward areas by nicotine
Neuron
(2000)
Neurobiological similarities in depression and drug dependence: a self-medication hypothesis
Neuropsychopharmacology
(1998)
Nicotine, brain nicotinic receptors, and neuropsychiatric disorders
Arch. Med. Res.
(2000)
Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice
Neuropharmacology
(2007)
The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo
Neuron
(2006)
lynx1, An endogenous toxin-like modulator of nicotinic acetylcholine receptors in the mammalian CNS
Neuron
(1999)
The effects of acute and repeated nicotine treatment on nucleus accumbens dopamine and locomotor activity
Br. J. Pharmacol.
(1992)
Evidence that tobacco smoking increases the density of (−)-[3H]nicotine binding sites in human brain
J. Neurochem.
(1988)
Functional expression of two neuronal nicotinic acetylcholine receptors from cDNA clones identifies a gene family
Proc. Natl. Acad. Sci. U.S.A.
(1987)
Cigarette smoking saturates brain alpha 4 beta 2 nicotinic acetylcholine receptors
Arch. Gen. Psychiatry
(2006)
Smoking-induced ventral striatum dopamine release
Am. J. Psychiatry
(2004)
beta2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice
Psychopharmacology
(2006)
Environmental stimuli promote the acquisition of nicotine self-administration in rats
Psychopharmacology
(2002)
Knockout and knockin mice to investigate the role of nicotinic receptors in the central nervous system
Prog. Brain Res.
(2004)
Distribution and pharmacology of alpha 6-containing nicotinic acetylcholine receptors analyzed with mutant mice
J. Neurosci.
(2002)
Allosteric mechanisms of signal transduction
Science
(2005)
Acetylcholine receptor: an allosteric protein
Science
(1984)
The effects of the DRD2 polymorphism on smoking cessation and negative affect: evidence for a pharmacogenetic effect on mood
Nicotine Tob. Res.
(2004)
Varenicline: an alpha4beta2 nicotinic receptor partial agonist for smoking cessation
J. Med. Chem.
(2005)
Perinatal exposure to nicotine causes deficits associated with a loss of nicotinic receptor function
Proc. Natl. Acad. Sci. U.S.A.
(2005)
Pentameric structure and subunit stoichiometry of a neuronal nicotinic acetylcholine receptor
Nature
(1991)
The mesolimbic dopaminergic system is implicated in the reinforcing effects of nicotine
Psychopharmacology
(1992)
Associative learning mediates dynamic shifts in dopamine signaling in the nucleus accumbens
Nat. Neurosci.
(2007)
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