Behavioural NeuroscienceResearch PaperLong-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Aβ1-42 oligomers and upregulating synaptic plasticity–related proteins in the hippocampus
Section snippets
Animals and supplementation
Male SAMP8 and accelerated senescence-resistant mouse prone-1 (SAMR1) mice were provided by the Department of Laboratory Animal Science of Peking University Health Science Center. Each mouse was individually housed per cage with a 12-h light/dark cycle under controlled temperature (23±2 °C) and humidity (50±10%). The animals had free access to food and water. After a 7 day acclimatization to the laboratory conditions, 4 month old SAMP8 mice (n=45) were randomly divided into three groups: SAMP8
GTC intake and body weights
Daily water intake per mouse did not differ among the SAMP8 control (5.39±0.20 ml/day), SAMR1 control (5.11±0.17 ml/day), 0.05% GTC-treated (5.40±0.21 ml/day) and 0.1% GTC-treated (5.15±0.22 ml/day) groups. The mean dose of GTC was therefore calculated to be about 75 and 150 mg/kg/day. Body weights of mice submitted to GTC treatment were similar to that of the SAMP8 control mice both at the beginning (SAMP8: 34.21±0.45 g; 0.05% GTC: 34.52±0.75 g; 0.1% GTC: 34.14±0.55 g) and at the end of the
Discussion
Recently, SAMP8 mice have drawn attention in gerontological research of dementia due to their characteristic early onset of cognitive deficits (Butterfield and Poon, 2005). SAMR1 mice, which are genetically related to SAMP8 but resistant to accelerated senescence, have always been used as normal control (Tajes et al., 2008). Previous studies indicated that SAMP8 mice show decrement of spatial learning and memory in MWM emerging at 8 months of age and deteriorate from then on (Chen et al., 2007
Conclusion
In conclusion, the primary finding of this study is that chronic GTC treatment may prevent spatial memory deficits in aged SAMP8 mice by modulating the Aβ cascade. Thus, drinking tea every day might be an effective habit in preventing the onset of AD and in ameliorating the memory defects in the early phases of the disease.
Acknowledgments
This work was supported by the foundation (No. 2006BAD27B08) from the Ministry of Science and Technology of the People's Republic of China.
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