Behavioural neuroscienceAuditory inhibitory gating in medial prefrontal cortex: Single unit and local field potential analysis
Section snippets
Chronic microelectrode implantation
Animals were anesthetized with xylazine (10 mg/kg) and ketamine (100 mg/kg), and surgery was conducted according to procedures as described in protocols approved by nationally approved guidelines for the care and use of animals (USDA and PHS). All procedures were approved by the Bowling Green State University Animal Care and Use Committee. A stereotaxic apparatus was used for the implantation of recording microwires (NB Laboratories, Denison, TX, USA) into mPFC (A +2.7, M ±0.7, D −3.0)
LFP database
A neuronal database was created for LFP responses. Across the entire set of recording wires, only one positive-going peak was consistently measured to satisfy criteria for significance. This potential, P60, was initially recorded with a 60 ms latency following the onset of tone stimuli (Fig. 1). As indicated in the Experimental Procedures section, LFP responses tone stimuli from each wire were required to be significantly (P<0.01) different in amplitude compared with a 1 s control window that
Discussion
The results of the present study provide direct support for mPFC in sensory IG and show that the inhibition can persist over an extended period at both the LFP and single unit level. These data are critical in order to expand in the analysis of IG toward investigating the functional significance of IG within the mPFC regions. Our general idea related to the functional properties of IG is that each brain region and subregions contain sets of intrinsic inhibitory circuits and these circuits
Acknowledgments
We would like to thank Drs. Jaak Panksepp, Vern Bingman, and William O’Brien for helpful input into the research design of the present study. The work was sponsored by the Bowling Green State University Sponsored Programs and Research Office by Research Incentive Grants to H.C.C. We have also received support from the Department of Psychology at Bowling Green State University. R.P.M. received a J.P. Scott Center for Neuroscience, Mind and Behavior dissertation fellowship that allowed him to
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2019, CellCitation Excerpt :Consistent with these results, we found that AC neurons entrain to tones repeating at 20 Hz, 40 Hz, and 80 Hz, and for faster frequencies neurons fire in response to a smaller fraction and at a wider range of phases relative to individual tones. Although there is extensive evidence that CA1 and mPFC neurons can respond to sensory cues including auditory stimuli (Aronov et al., 2017; Mears et al., 2006; Miller and Freedman, 1995), we show for the first time that 40 Hz auditory, or A+V, stimulation elicits small but significant firing rate entrainment at 40 Hz in these brain regions (Figures 1B, 1H, 1N, and 6A–6C). As in AC, single units in CA1 and mPFC show modulation, meaning the firing rate changed as a function of stimulus phase, although they do not fire in response to every pulse.
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