Neuron
Volume 107, Issue 2, 22 July 2020, Pages 338-350.e5
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Article
Experience-Dependent Reorganization Drives Development of a Binocularly Unified Cortical Representation of Orientation

https://doi.org/10.1016/j.neuron.2020.04.022Get rights and content
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Highlights

  • Monocular stimulation at eye opening yields two distinct orientation representations

  • Binocular stimulation at eye opening yields a third distinct orientation representation

  • Experience-dependent processes drive development of a single unified representation

  • Shifts in cellular preferred orientation contribute to this functional reorganization

Summary

Across sensory areas, neural microcircuits consolidate streams of information into unified representations of the external world. In the carnivore visual cortex, where eye-specific inputs first converge, it has been posited that a single, binocularly aligned modular orientation representation develops independent of sensory experience. In this study of ferret visual cortex using in vivo calcium imaging, we find evidence for a different developmental process. Early in development, contralateral, ipsilateral, or binocular stimulation each yield well-organized modular representations of orientation that display features of mature cortex. However, comparison of these representations reveals considerable misalignment that is evident at both modular and cellular scales. Experience-dependent processes drive reorganization of these three representations toward a single binocularly aligned representation resembling the early binocular representation through shifts in cellular orientation preference. Thus, while orderly modular networks of orientation preference initially arise independent of visual experience, experience is critical for the alignment of these early representations.

Keywords

visual cortex
orientation
binocular
development
ferret
reorganization

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