Neuron
Volume 97, Issue 6, 21 March 2018, Pages 1356-1368.e4
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Article
Volitional Modulation of Primary Visual Cortex Activity Requires the Basal Ganglia

https://doi.org/10.1016/j.neuron.2018.01.051Get rights and content
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Highlights

  • Rodents learn to produce activity patterns in V1 in order to receive a reward

  • Visual cortex neurons are volitionally modulated in the absence of visual input

  • Inhibition of DMS impairs learning, but not production of learned patterns

  • Basal ganglia circuits play a general role in shaping cortical activity

Summary

Animals acquire behaviors through instrumental conditioning. Brain-machine interfaces have used instrumental conditioning to reinforce patterns of neural activity directly, especially in frontal and motor cortices, which are a rich source of signals for voluntary action. However, evidence suggests that activity in primary sensory cortices may also reflect internally driven processes, instead of purely encoding antecedent stimuli. Here, we show that rats and mice can learn to produce arbitrary patterns of neural activity in their primary visual cortex to control an auditory cursor and obtain reward. Furthermore, learning was prevented when neurons in the dorsomedial striatum (DMS), which receives input from visual cortex, were optogenetically inhibited, but not during inhibition of nearby neurons in the dorsolateral striatum. After learning, DMS inhibition did not affect production of the rewarded patterns. These data demonstrate that cortico-basal ganglia circuits play a general role in learning to produce cortical activity that leads to desirable outcomes.

Keywords

brain-machine interface
visual cortex
striatum
learning
optogenetics
instrumental conditioning

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