Neuron
Volume 87, Issue 1, 1 July 2015, Pages 193-207
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Article
An Interglomerular Circuit Gates Glomerular Output and Implements Gain Control in the Mouse Olfactory Bulb

https://doi.org/10.1016/j.neuron.2015.06.019Get rights and content
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Highlights

  • Broadcast of odor concentration signals by DAT+ cells throughout the glomerular layer

  • Gain control of OB output by DAT+ cells leads to decorrelated odor representations

  • DAT+ cells act on M/T cells via chemical and electrical synapses with ET cells

  • ET cells are gatekeepers of glomerular output and control M/T responsiveness

Summary

Odors elicit distributed activation of glomeruli in the olfactory bulb (OB). Crosstalk between co-active glomeruli has been proposed to perform a variety of computations, facilitating efficient extraction of sensory information by the cortex. Dopaminergic/GABAergic cells in the OB, which can be identified by their expression of the dopamine transporter (DAT), provide the earliest opportunity for such crosstalk. Here we show in mice that DAT+ cells carry concentration-dependent odor signals and broadcast focal glomerular inputs throughout the OB to cause suppression of mitral/tufted (M/T) cell firing, an effect that is mediated by the external tufted (ET) cells coupled to DAT+ cells via chemical and electrical synapses. We find that DAT+ cells implement gain control and decorrelate odor representations in the M/T cell population. Our results further indicate that ET cells are gatekeepers of glomerular output and prime determinants of M/T responsiveness.

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