Neuron
Volume 52, Issue 3, 9 November 2006, Pages 437-444
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Arc/Arg3.1 Is Essential for the Consolidation of Synaptic Plasticity and Memories

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Summary

Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.

SYSNEURO
SIGNALING
PROTEINS

Cited by (0)

9

These authors contributed equally to this work.

10

Present address: H.Lundbeck A/S, Disease Pharmacology, 2500 Valby, Denmark.

11

Present address: Emory University School of Medicine, Atlanta, Georgia 30322.

12

Present address: Central Institute for Mental Health, J5, 68159 Mannheim, Germany.

13

Present address: Charite, Neurologische Klinik, Campus Virchow Klinikum, 13353 Berlin, Germany.

14

Present address: MPI of Neurobiology, 82152 Martinsried, Germany.