Elsevier

NeuroImage

Volume 42, Issue 2, 15 August 2008, Pages 936-944
NeuroImage

The functional anatomy of the MMN: A DCM study of the roving paradigm

https://doi.org/10.1016/j.neuroimage.2008.05.018Get rights and content

Abstract

Using dynamic causal modelling (DCM), we have presented provisional evidence to suggest: (i) the mismatch negativity (MMN) is generated by self-organised interactions within a hierarchy of cortical sources [Garrido, M.I., Kilner, J.M., Kiebel, S.J., Stephan, K.E., Friston, K.J., 2007. Dynamic causal modelling of evoked potentials: a reproducibility study. NeuroImage 36, 571–580] and (ii) the MMN rests on plastic change in both extrinsic (between-source) and intrinsic (within source) connections (Garrido et al., under review). In this work we re-visit these two key issues in the context of the roving paradigm. Critically, this paradigm allows us to discount any differential response to differences in the stimuli per se, because the standards and oddballs are physically identical. We were able to confirm both the hierarchical nature of the MMN generation and the conjoint role of changes in extrinsic and intrinsic connections. These findings are consistent with a predictive coding account of repetition–suppression and the MMN, which gracefully accommodates two important mechanistic perspectives; the model-adjustment hypothesis [Winkler, I., Karmos, G., Näätänen, R., 1996. Adaptive modelling of the unattended acoustic environment reflected in the mismatch negativity event-related potential. Brain Res. 742, 239–252; Näätänen, R., Winkler, I., 1999. The concept of auditory stimulus representation in cognitive neuroscience. Psychol Bull 125, 826–859; Sussman, E., Winkler, I., 2001. Dynamic sensory updating in the auditory system. Brain Res. Cogn Brain Res. 12, 431–439] and the adaptation hypothesis [May, P., Tiitinen, H., Ilmoniemi, R.J., Nyman, G., Taylor, J.G., Näätänen, R., 1999. Frequency change detection in human auditory cortex. J. Comput. Neurosci. 6, 99–120; Jääskeläinen, I.P., Ahveninen, J., Bonmassar, G., Dale, A.M., Ilmoniemi, R.J., Levänen, S., Lin, F.H., May, P., Melcher, J., Stufflebeam, S., Tiitinen, H., Belliveau, J.W., 2004. Human posterior auditory cortex gates novel sounds to consciousness. Proc. Natl. Acad. Sci. U. S. A. 101, 6809–6814].

Introduction

Novel events, or oddballs, embedded in a stream of repeated events, or standards, produce a distinct response that can be recorded non-invasively with electrophysiological techniques such as electroencephalography (EEG). The mismatch negativity (MMN) is one of the ERP components elicited by any discriminable violation in the acoustic regularity. The MMN is believed to be an index of automatic change detection governed by a pre-attentive sensory memory mechanism (Näätänen, 1990). Despite being the subject of much research, the mechanisms behind MMN generation remain a topic of much debate. Recently, we provided evidence that the mechanisms underlying the MMN can be considered within a hierarchical inference or predictive coding framework (Garrido et al., 2007). Within this account the MMN is interpreted as a failure to suppress prediction error, which can be explained quantitatively in terms of coupling changes among and within cortical regions. The predictive coding framework encompasses two previous hypotheses that have been debated in the literature; the adaptation hypothesis (May et al., 1999, Jääskeläinen et al., 2004) and the model-adjustment hypothesis (Winkler et al., 1996, Näätänen and Winkler, 1999, Sussman and Winkler, 2001). While the latter allows for adaptation effects (which the authors refer to as refractoriness), the adaptation hypothesis precludes a prediction or model-dependent contribution to the MMN. Predictive coding entails both adjustments to a generative model of stimulus trains and adaptation due to the increasing precision of predictions. We tested the relative contributions of model-adjustment and adaptation by formulating them as network models with plastic changes in extrinsic (model-adjustment) and intrinsic (adaptation) connections. We show that both model-learning and adaptation contribute to the MMN, consistent with predictive coding or model based explanations (Friston et al., 2006, Winkler, 2007).

It has been suggested that stimulus repetition engenders an echoic memory trace, which compares preceding and current stimuli (Näätänen, 1992). The MMN increases with the number of repetitions of a standard stimulus and is believed to reflect the strength of this trace (Sams et al., 1993). Repetition in roving paradigms, which are characterised by sporadic changes in the frequency of a repeating tone, enhance a slow positive wave from 50 to 250 ms post-stimulus in the standard ERP; the repetition positivity (RP) (Baldeweg et al., 2004). Both RP and MMN increase with repetitions of standards, suggesting that these are the ERP correlates of sensory memory formation and are (the same) electrophysiological signatures of sensory learning (Haenschel et al., 2005).

In the predictive coding framework (see also Friston, 2005, Baldeweg, 2006), evoked responses, corresponding to prediction error, drive perceptual inference (within-trial) and changes in connectivity (between trials) so that prediction error is suppressed with learning. Previously, we used dynamic causal models (DCMs) to explore network models underlying mismatch or oddball responses (Garrido et al., under review). This was achieved by explaining differences in the ERP evoked by standard and deviant tones on the basis of plastic changes within a cortical network. DCM models every time-bin and every channel in a single analysis and attempts to explain differences in the evoked responses, including the MMN and other components such as the N1 (Näätänen et al., 2005), in terms of changes in connection strengths. Our previous study employed a classical oddball paradigm, which meant that any differences in between ERPs evoked by standard and deviant tones could have been driven by a stimulus-specific N1 response as well a pure MMN response. Here we used a roving paradigm, where there were no acoustic differences between the standard and deviant. This ensured that any differences could not be explained stimulus-specific differences in the N1 contribution and enabled us to model the MMN per se.

In short, the key contributions of this study are firstly, to demonstrate the validity of the mechanism for MMN generation that we have proposed previously (Garrido et al., under review), and secondly, to show that the ensuing mismatch responses are due to learning and not to stimuli differences per se.

Section snippets

Stimuli

We studied twelve healthy volunteers aged 24–34 (4 female). Each subject gave signed informed consent before the study, which proceeded under local ethical committee guidelines. Subjects sat in front of a desk in a dimly illuminated room. Electroencephalographic activity was measured during an auditory roving ‘oddball’ paradigm (see Fig. 1a). The stimuli comprised a structured sequence of pure sinusoidal tones, with a roving, or sporadically changing tone. This paradigm resulted from few

Results

Learning the acoustic environment through stimulus repetition changes connectivity within and between hierarchically organised cortical areas. This analysis comprised three parts: (i) confirmation that there is a significant differential response (MMN) between the first and sixth tone presentation; (ii) model selection to identify the most likely number and hierarchical deployment of sources causing these responses and (iii) hypotheses or model testing to establish that the MMN is mediated by

Discussion

Using dynamic causal modelling, we have presented further evidence to suggest: (i) the mismatch negativity (MMN) is generated by self-organised interactions within a hierarchy of cortical sources (Garrido et al., 2007) and (ii) the MMN rests on plastic change in both extrinsic (between-source) and intrinsic (within source) connections (Garrido et al.; under review). Critically, these conclusions are consistent with previous analysis of a conventional oddball paradigm but can now be generalised

Acknowledgments

The Wellcome Trust and the Portuguese Foundation for Science and Technology funded this work. We thank David Bradbury for technical support and the volunteers for participating in this study.

All the software necessary to implement these analyses are available as part of the SPM academic freeware (http://www.fil.ion.ucl.ac.uk/spm).

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