Metabotropic glutamate mGlu2 receptor is necessary for the pharmacological and behavioral effects induced by hallucinogenic 5-HT2A receptor agonists
Research highlights
► Head-twitch behavior induced by hallucinogenic 5HT2A agonists is abolished in mGlu2-KO mice. ► Cellular response induced by hallucinogenic 5HT2A agonists is abolished in mGlu2-KO mice. ► This suggests the 5HT2A-mGlu2 complex as necessary for the responses induced by hallucinogens.
Section snippets
Acknowledgements
NIMH 5R01MH084894 (J.G.M.), NIDA P01 DA12923 (S.C.S.), NARSAD (J.G.M.), and the Maltz Family Foundation (J.G.M.) participated in the funding of this study. We are grateful to Dr. J.A. Gingrich for his gift of 5-HT2AR-KO mice. J.L.M was the recipient of a postdoctoral fellowship from Ministerio de Ciencia e Innovación, Spain.
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