Acute and chronic morphine alters formalin pain in neonatal rats
References (43)
- et al.
Mu and delta opioid receptor-like immunoreactivity in the cervical spinal cord of the rat after dorsal rhizotomy or neonatal capsaicin: an analysis of pre- and postsynaptic receptor distributions
Brain Res.
(2002) - et al.
Effects of morphine, pentobarbital and amphetamine on formalin-induced behaviours in infant rats: sedation versus specific suppression of pain
Pain
(1995) - et al.
Building blocks of pain: the regulation of key molecules in spinal sensory neurones during development and following peripheral axotomy
Pain
(1999) - et al.
Long-term behavioral effects of repetitive pain in neonatal rat pups
Physiol. Behav.
(1999) Antinociceptive effects of locally administered morphine in infant rats
Pain
(1999)- et al.
Mu- and delta-opioid receptors are downregulated in the largest diameter primary sensory neurons during postnatal development in rats
Pain
(2001) - et al.
Is the brain hormonally imprintable?
Brain Dev.
(2005) - et al.
Opioid receptor subtypes in the rat spinal cord: electrophysiological studies with mu- and delta-opioid receptor agonists in the control of nociception
Brain Res.
(1987) - et al.
The behavioral response to formalin in preweanling rats
Pain
(1992) - et al.
Afferent fiber selective shift in opiate potency following targeted opioid receptor knockdown
Pain
(2003)
The functional expression of mu opioid receptors on sensory neurons is developmentally regulated; morphine analgesia is less selective in the neonate
Pain
Nitrous oxide exerts age-dependent antinociceptive effects in Fischer rats
Pain
Spatial and temporal aspects of spinal cord and brainstem activation in the formalin pain model
Prog. Neurobiol.
Postnatal development of multiple opioid receptors in the spinal cord and development of spinal morphine analgesia
Brain Res. Dev. Brain Res.
Development of spinal opioid systems
Reg. Anesth. Pain Med.
Isoflurane exerts antinociceptive and hypnotic properties at all ages in Fischer rats
Br. J. Anaesth.
Learning in sensorimotor circuits
Curr. Opin. Neurobiol.
Acute and chronic ethanol exacerbates formalin pain in neonatal rats
Neurosci. Lett.
Nociception and antinociception during the first week of life in mice: sex differences and test dependence
J. Pain
Effect of neonatal circumcision on pain response during subsequent routine vaccination
Lancet
The formalin test: a dose-response analysis at three developmental stages
Pain
Cited by (11)
Surgery, Anesthesia, and the Immature Brain
2019, A Practice of Anesthesia for Infants and ChildrenSurgery, Anesthesia, and the Immature Brain
2018, A Practice of Anesthesia for Infants and ChildrenMorphine exposure during early life alters thermal and mechanical thresholds in rats
2017, International Journal of Developmental NeuroscienceCitation Excerpt :Furthermore, it has been demonstrated that neonatal manipulations are capable of displaying long-lasting alterations; for example, neonatal stress exaggerates adult arousal, whereas neonatal morphine treatment reduces adult arousal (Boasen et al., 2009). Besides, short-term effects can be observed after neonatal morphine treatment, where rats acutely or chronically exposed to morphine displayed increased phase II pain-associated behaviors in formalin test at P11 (Zissen et al., 2006). Moreover, hippocampal structure changes were observed after recurrent morphine administration during brain development (Traudt et al., 2012).
Behavioral effects of perinatal opioid exposure
2014, Life SciencesCitation Excerpt :Intraplantar formalin-induced pain reactions were reduced by acute morphine treatment in neonates (Abbott and Guy, 1995). However, when the postnatal morphine administration was followed by 4 days of abstinence, the pain reaction increased significantly (Zissen et al., 2006). Similarly, antinociceptive tolerance to morphine administration developed, as measured by a hot plate test (Bajic et al., 2013).
Morphine exposure in early life increases nociceptive behavior in a rat formalin tonic pain model in adult life
2011, Brain ResearchCitation Excerpt :Thus, the increase in formalin-induced nociceptive behavior observed in this study suggests a central hyperexcitability of the ascending second-order dorsal horn neurons induced by previous sustained exposure to morphine, and this is a long-term effect. Our results agree with those of Zissen et al. (2006, 2007), who have demonstrated that while infant rats (P5 to P8) are more sensitive to the long-term changes in formalin-induced pain and mechanical thresholds following continuous exposure to morphine, when compared to young rats (P19 to P21), they are also better able to compensate for changes in mechanical thresholds following intermittent administration of morphine, given twice a day for 3 days. It is possible that short bouts of morphine withdrawal-induced excitation may off-set morphine-induced inhibition in infants, but not in young rats, and thus, may better maintain the balance of activity and inactivity during this crucial developmental phase.
Congenital hypothyroidism alters formalin-induced pain response in neonatal rats
2009, International Journal of Developmental NeuroscienceCitation Excerpt :These behavioral reflexes are considered the most sensitive and specific measures of pain (Guy and Abbott, 1992). It has been shown that the opioid analgesia attenuates these specific pain behaviors in 2-week-old rats (Zissen et al., 2006). In accordance, the maturation of C-fiber input to the spinal cord is completed around the second postnatal week (Jenning and Fitzgerald, 1998).