Behavioral effects of metyrapone on Pavlovian extinction
Section snippets
Acknowledgments
This work was supported in part by National Institutes of Health grant R01 NS37755 to F. Gonzalez-Lima. The authors thank J. Shumake, J. Wommack, and Y. Delville for technical assistance.
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2021, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Indeed, systemic administration of metyrapone, as well as intra-amygdala infusion of mifepristone, a glucocorticoid receptor antagonist, disrupted extinction learning (Yang et al., 2006). In slight contrast, another study found that systemic administration of metyrapone did not impact extinction learning, though later increases in spontaneous recovery and renewal were observed, suggesting that blocking corticosterone synthesis disrupts extinction memory consolidation (Barrett and Gonzalez-Lima, 2004). These and further studies highlighted below, raise the interesting possibility that endogenous glucocorticoid activity scales with threat predictability, whereby a lack of glucocorticoids disrupts threat response regulation by impairing learning processes about the actual likelihood of threat, whereas elevated glucocorticoid levels lead to generalization of threat assignment.
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