Over-expression of the fyn-kinase gene reduces hypnotic sensitivity to ethanol in mice
Section snippets
Acknowledgments
The authors would like to thank Virginia Bleck and Elizabeth Osterndorff-Kahanek for their excellent technical assistance. These experiments were supported by NIAAA (AA07471, AA13520, AA06399, AA14455).
References (21)
- et al.
Differential modulation of GABA- and NMDA-gated currents by ethanol and isoflurane in cultured rat cerebral cortical neurons
Brain Res.
(2001) - et al.
Resistance to ethanol withdrawal-induced behaviour in fyn transgenic mice and its reversal by ifenprodil
Brain Res. Mol. Brain Res.
(2002) - et al.
Fyn tyrosine kinase reduces the ethanol inhibition of recombinant NR1/NR2A but not NR1/NR2B NMDA receptors expressed HEK 293 cells
J. Neurochem.
(1999) - et al.
Deletion of the fyn-kinase gene alters behavioral sensitivity to ethanol
Alcohol Clin. Exp. Res.
(2003) - et al.
Deletion of the fyn-kinase gene alters sensitivity to GABAergic drugs: dependence on β2/β3 GABAA receptor subunits
J. Pharmacol. Exp. Ther.
(2004) - et al.
Role of fyn tyrosine kinase in ethanol consumption by mice
Alcohol Clin. Exp. Res.
(2003) - et al.
Genetic selection and characterization of mouse lines for acute functional tolerance to ethanol
J. Pharmacol. Exp. Ther.
(1996) - et al.
Mutant mice lacking the γ isoform of protein kinase C show decreased behavioral actions of ethanol and altered function of γ-aminobutyrate type A receptors
Proc. Natl. Acad. Sci. U.S.A.
(1995) - et al.
Abnormal synaptic transmission in olfactory bulb of fyn-kinase-deficient mice
J. Neurophysiol.
(1998) - et al.
Higher seizure susceptibility and enhanced tyrosine phosphorylation of N-ethyl-d-aspartate receptor subunit 2B in fyn transgenic mice
Learn. Mem.
(1998)
There are more references available in the full text version of this article.
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2011, Trends in NeurosciencesCitation Excerpt :Fyn-deficient mice manifest an increase in the duration of the ethanol-induced loss of righting reflex (LORR) [58–60], which is used to determine hypnotic sensitivity to ethanol. By contrast, LORR was found to be significantly decreased in mice that overexpress Fyn in the adult forebrain under the control of αCaMKII promoter [61]. Fyn-deficient mice also exhibited impaired acute tolerance to the motor incoordinating effects of ethanol as measured by the use of the stationary dowel [59].
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